SAB2500781

Anti-PGC1A antibody produced in goat

affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-LEM6, Anti-PPARGC1A, Anti-Peroxisome proliferator-activated receptor γ
• Número MDL: MFCD02263906
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: goat
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• reactividad de especies: human, mouse, canine, rat
• técnicas: indirect ELISA: suitable; western blot: suitable
• Nº de acceso UniProt: Q9UBK2
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... PPARGC1A(10891)

Descripción

Descripción general

Peroxisome proliferator-activated receptor γ (PPARG) coactivator 1 α (PPARGC1A) encodes the 798 amino acid protein, PGC-1α. It is a multifunctional transcriptional protein, which belongs to the family of transcription co-activators involved in the regulation of cellular energy metabolism. PGC-1α is abundantly expressed in several human tissues that are active in oxidative metabolism, including heart, skeletal muscle, and the fasted liver. The gene encoding this protein is localized on human chromosome 4p15.1-2.

Inmunógeno

Peptide with sequence C-DGLFDDSEDESDK from the internal region of the protein sequence according to NP_037393.1.

Aplicación

Anti-PGC1A antibody produced in goat has been used in Western blotting.

Acciones bioquímicas o fisiológicas

Peroxisome proliferator-activated receptor γ (PPARG) coactivator 1 α (PPARGC1A) modulates the expression of mitochondrial oxidative phosphorylation (OXPHOS) genes and endogenous antioxidants. Variation in the gene expression leads to Huntington′s disease (HD) and Type 2 diabetes. PGC-1α functions as a ‘molecular switch′ in genetic pathways involved in maintaining glucose homeostasis in liver and muscle, β cell insulin secretion and mitochondrial biogenesis. Addition to this, PGC-1α has a crucial role to play in adaptive thermogenesis, skeletal muscle fiber type switching and heart development. PGC-1α reduces or improves muscle dystrophy by stimulating various molecular pathways; therefore, increase in the concentration and activity of PGC-1 is considered to be a potential method for Duchene muscular dystrophy (DMD) treatment.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable