SAB1410861

Anti-OPRL1 antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

• Sinónimos: KOR-3, MGC34578, NOCIR, OOR, ORL1
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: antigen 40.7 kDa
• reactividad de especies: human
• técnicas: western blot: 1 μg/mL
• Nº de acceso NCBI: NM_000913
• Nº de acceso UniProt: P41146
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... OPRL1(4987)

Descripción

Descripción general

Opioid related nociceptin receptor 1 (OPRL1) is mapped to human chromosome 20q13.33. The gene codes for the nociceptin/orphanin FQ receptor (NOP-R), which is a G protein-coupled receptor expressed at various levels all over the brain and spinal cord. OPRL1 belongs to the opioid receptor family.

The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene, regulator of G-protein signalling 19 (RGS19), located on the opposite strand. Two transcript variants encoding the same protein have been found for this gene. (provided by RefSeq)

Inmunógeno

OPRL1 (NP_000904.1, 1 a.a. ~ 370 a.a) full-length human protein.

Sequence
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA

Acciones bioquímicas o fisiológicas

Opioid related nociceptin receptor 1 (OPRL1) plays a vital role in alcohol and other drug reward pathways. The encoded protein is involved in regulating tolerance and behavioral responses to morphine. Phosphorylation of NOPR at serine 363 by G protein-coupled receptor kinase 3 (GRK3) facilitates arrestin-dependent Jun amino-terminal kinases (JNK) mitogen-activated protein kinase (MAPK) signaling. Mutation in the gene is associated with the risk to develop opiate addiction.

Forma física

Solution in phosphate buffered saline, pH 7.4

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable