SAB1305415

ANTI-MLCK(N-TERMINAL) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Sinónimos: Myosin light chain kinase
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: IgG fraction of antiserum
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: 210715 Da
• reactividad de especies: human, mouse
• técnicas: immunohistochemistry: 1:50-1:100; western blot: 1:1000
• Nº de acceso NCBI: NP_444253.3
• Nº de acceso UniProt: Q15746
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... MYLK(4638)

Descripción

Descripción general

Myosin light chain kinase (MLCK) is a serine/threonine kinase and the gene encoding it is localized on human chromosome 3q21.1.

Acciones bioquímicas o fisiológicas

Myosin light chain kinase (MLCK) is activated by the binding of Ca²⁺/calmodulin. It has a role in smooth muscle contraction. The kinase phosphorylates the regulatory light chain of smooth muscle myosin. This stimulates ATPase activity of the myosin heads and leads to the myosin power stroke, which is crucial for muscle contraction. MLCK also assists the interaction of myosin with actin. Loss of function of the protein has been linked to megacystis microcolon intestinal hypoperistalsis syndrome.

Forma física

Supplied in PBS with 0.09% (W/V) sodium azide

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable