SAB1300669

Anti-SULT2B1a/b (N-term) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Sinónimos: Anti-Alcohol sulfotransferase, Anti-HSST2, Anti-Hydroxysteroid sulfotransferase SULT2B1b, Anti-Sulfotransferase family, cytosolic, 2B, member 1, isoform b
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: IgG fraction of antiserum
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• reactividad de especies: human
• técnicas: indirect ELISA: 1:1000; western blot: 1:100-1:500
• Nº de acceso NCBI: NP_004596
• Nº de acceso UniProt: O00204
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... SULT2B1(6820)

Descripción

Descripción general

Cytosolic sulfotransferases (STs or SULTs) encodes hydroxysteroid sulfotransferase (SULT2B1), the isoforms of which are SULT2B1a and SULT2B1b. By PCR with human placental and prostate cDNA as template, they isolated 2 alternatively spliced cDNAs, identical throughout most of their sequences, but having different 5-prime ends. The shorter cDNA, SULT2B1a, encodes a protein of 350 amino acids; the longer cDNA, SULT2B1b, encodes a 365-amino acid protein. Genomic PCR analysis revealed that the gene encoding both cDNAs, SULT2B1, contains 7 exons, with 2 alternative first exons being used to generate SULT2B1a and SULT2B1b. Northern blot analysis revealed that the SULT2B1 gene is expressed as a 1.4-kb transcript predominantly in prostate, placenta, and trachea. In human chromosome, the gene SULT2B1a/b is localized on 19q13.3.

Inmunógeno

SULT2B1A/B (NP_004596, 1-30)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human SULT2B1a/b.

Acciones bioquímicas o fisiológicas

Cytosolic sulfotransferases (STs or SULTs) catalyse the sulfate conjugation of many drugs, xenobiotic compounds, hormones, and neurotransmitters. SULT2B1 is involved in the synthesis and metabolism of steroids, which is essential for skin development and skin barrier function. Mutations in SULT2b1a/b gene leads to increased keratinocyte proliferation and altered cholesterol metabolism, resulting in autosomal-recessive congenital ichthyosis (ARCI). SULT2B1 catalyses the sulfation of an androgen precursor, dehydroepiandrosterone (DHEA) and hence polymorphism within this gene may lead to prostate tumor.

Forma física

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable