S8626

Sulfadiazine

99.0-101.0%

• Sinónimos: 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide, N¹-(Pyrimidin-2-yl)sulfanilamide
• Fórmula empírica (notación de Hill): C₁₀H₁₀N₄O₂S
• Número de CAS: 68-35-9
• Peso molecular: 250.28
• Beilstein: 6733588
• Número CE: 200-685-8
• Número MDL: MFCD00006065
• Código UNSPSC: 51283908
• ID de la sustancia en PubChem: 24899802
• NACRES: NA.85

Propiedades

• descripción: Solubility - Practically insoluble in water, slightly soluble in acetone, very slightly soluble in ethanol (96 per cent). It dissolves in solutions of alkali hydroxides and in dilute mineral acids.
• Nivel de calidad: 200
• Ensayo: 99.0-101.0%
• Formulario: powder or crystals
• color: white to faint yellow, faint pink
• mp: 253 °C (dec.) (lit.)
• solubilidad: 96% ethanol: very slightly soluble; acetone: slightly soluble; water: practically insoluble
• espectro de actividad antibiótica: Gram-negative bacteria; Gram-positive bacteria; mycoplasma
• Modo de acción: DNA synthesis | interferes; enzyme | inhibits
• cadena SMILES: Nc1ccc(cc1)S(=O)(=O)Nc2ncccn2
• InChI: 1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)
• Clave InChI: SEEPANYCNGTZFQ-UHFFFAOYSA-N

Descripción

Descripción general

Chemical structure: sulfonamide

Aplicación

Sulfadiazine is a short-acting sulfonamide that is commonly used with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome. It is also used to treat newborns with congenital infections. Sulfadiazine has been used to control acute infections when studying murine models of reactivated toxoplasmosis.

Acciones bioquímicas o fisiológicas

Sulfadiazine is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Otras notas

Keep container tightly closed in a dry and well-ventilated place.Storage class (TRGS 510): Non Combustible Solids

Información de seguridad

• Pictogramas: GHS08,GHS07,GHS09
• Palabra de señalización: Warning
• Frases de peligro: H302,H361d,H411
• Consejos de prudencia: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Clasificaciones de peligro: Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves