S5566

Anti-α-Synuclein antibody, Mouse monoclonal

clone Syn211, purified from hybridoma cell culture

• Sinónimos: Anti-SNCA
• Número MDL: MFCD02095740
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 200
• conjugado: unconjugated
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: Syn211, monoclonal
• formulario: buffered aqueous solution
• mol peso: antigen 19 kDa
• reactividad de especies: zebra finch, human
• no debe reaccionar con: rat, mouse
• envase: antibody small pack of 25 μL
• concentración: ~1 mg/mL
• técnicas: immunohistochemistry: suitable; immunoprecipitation (IP): suitable; western blot: 0.25 μg/mL using recombinant human α·-synuclein.
• isotipo: IgG1
• Nº de acceso UniProt: P37840
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... SNCA(6622)

Descripción

Descripción general

The SNCA (synuclein α) gene codes for a 140-amino acid protein α-synuclein, that is mapped to human chromosome 4q21-23.

The SNCA (synuclein α) gene is mapped to human chromosome 4q22.1. The gene encodes a small synaptic protein called α-synuclein.

Inmunógeno

recombinant human α synuclein.

Aplicación

Anti-α-Synuclein antibody, Mouse monoclonal has been used in western blotting and ELISA.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Flow cytometry/Cell sorting (1 paper)
Immunocytochemistry (1 paper)

Acciones bioquímicas o fisiológicas

Accumulation of α-synuclein in oligodendrocytes results in the loss of myelin and causes neurodegeneration, leading to multiple system atrophy. Synuclein-α is known to induce oligodendrocyte maturation. The encoded protein is considered to be an important aggregate of Lewy bodies, contributing to the pathogenesis of Parkinson disease.

Synuclein-α is known to induce oligodendrocyte maturation. Accumulation of α-synuclein in oligodendrocytes results in the loss of myelin and causes neurodegeneration, leading to multiple system atrophy. Mutations in the SNCA gene results in Parkinson′s disease.

Forma física

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 1 % bovine serum albumin and 15 mM sodium azide.

Otras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable