S2071

Anti-Sodium Channel Na_V1.8 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Sinónimos: Anti-PN3, Anti-SCN10A
• Número MDL: MFCD08705520
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 200
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: lyophilized powder
• reactividad de especies: rat
• técnicas: immunohistochemistry (frozen sections): suitable using adult rat DRG; western blot: 1:200 using rat DRG lysates
• Nº de acceso UniProt: Q62968
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... SCN10A(6336) ; mouse ... Scn10a(20264) ; rat ... Scn10a(29571)

Descripción

Descripción general

Sodium voltage-gated channel α subunit 10 (SCN10A) codes for Nav1.8 sodium channels. It is expressed in nociceptive neurons. This gene is mapped to human chromosome 3p22.2.

Inmunógeno

peptide (C)EDEVAAKEGNSPGPQ corresponding to residues 1943-1957 of rat Na_v1.8. This sequence has 14/15 residues identical in mouse and 7/15 residues identical in human.

Aplicación

Anti-Sodium Channel NaV1.8 antibody has been used in immunohistochemistry and immunocytochemistry.

Acciones bioquímicas o fisiológicas

Sodium voltage-gated channel α subunit 10 (SCN10A) plays a major role in human pain. It is involved in the pathophysiology of cerebellar deficits in MS (multiple sclerosis).

Descripción de destino

Anti-Sodium Channel Na_V1.8 specifically recognizes Na_V1.8. Voltage-gated sodium channels (VGSCs) are present in most excitable cells. They play a crucial role in regulating the cell excitability, being primarily responsible for the

Forma física

Lyophilized from phosphate buffered saline, pH 7.4, with 1% bovine serum albumin, and 0.05 % sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 13 - Non Combustible Solids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable