S193

Anti-Synapsin I antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Sinónimos: Anti-EPILX, Anti-MRX50, Anti-SYN1a, Anti-SYN1b, Anti-SYNI
• Número MDL: MFCD00282157
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: lyophilized powder
• mol peso: antigen ~80 kDa (Synapsin Ia)
• reactividad de especies: rat, mouse, human, bovine
• técnicas: dot blot: 1:1000; immunohistochemistry (frozen sections): 1:2000; immunoprecipitation (IP): 1 μg; indirect immunofluorescence: 1:2000; western blot: 1:1000
• Nº de acceso UniProt: P17600
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... SYN1(6853) ; mouse ... Syn1(20964) ; rat ... Syn1(24949)

Descripción

Descripción general

Synapsin I (1a and 1b) refers to two nearly identical phosphoproteins found in the cytoplasmic surface of synaptic vesicles of the CNS (central nervous system) and PNS(peripheral nervous system). It may be used to localize and detect synapsin I (synapsins Ia and Ib are collectively referred to as synapsin I) in nerve terminals.The SYN1 gene is mapped to human chromosome Xp11.3-p11.23.

Inmunógeno

synapsin I from bovine brain.

Aplicación

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.

• Western Blotting (1 paper)
• immunohistochemistry
• immunoblotting
• immunoprecipitation
• ELISA.

Rabbit polyclonal anti-Synapsin I antibody can be used for the localization and detection of synapsin I (synapsins Ia and Ib, approximately 80 kDa and 77 kDa, are collectively referred to as synapsin I) in nerve terminals.

Acciones bioquímicas o fisiológicas

Synapsin I is involved in the regulation of axonogenesis and synaptogenesis wherein it serves as a substrate of various protein kinases including those activated by cAMP, calciuim/calmodulin, mitogens, and cyclins. The antibody strongly reacts with the synapsin I doublet. Synapsin I is associated with vesicle trafficking. Mutation in this gene is one of the known cause for familial epilepsy and autism spectrum disorders.

Forma física

Lyophilized from ammonium bicarbonate (5 mM)

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 13 - Non Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)