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Q1004

Sigma-Aldrich

Quipazine maleate salt

Sinónimos:

2-(1-Piperazinyl)quinoline maleate salt

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About This Item

Fórmula empírica (notación de Hill):
C13H15N3 · C4H4O4
Número de CAS:
5786-68-5
Peso molecular:
329.35
Número CE:
227-314-2
Número MDL:
MFCD00133796
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24278122
NACRES:
NA.77

solubilidad

H2O: soluble
alcohol: soluble
dilute aqueous acid: soluble

Nivel de calidad

200

temp. de almacenamiento

2-8°C

cadena SMILES

OC(=O)\C=C/C(O)=O.C1CN(CCN1)c2ccc3ccccc3n2

InChI

1S/C13H15N3.C4H4O4/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16;5-3(6)1-2-4(7)8/h1-6,14H,7-10H2;1-2H,(H,5,6)(H,7,8)/b;2-1-

Clave InChI

QYJJDHZHSCTBII-BTJKTKAUSA-N

Información sobre el gen

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363)

Aplicación

Quipazine maleate salt has been used as a serotonin receptor agonist to study its effects on mouse models with spinal cord injury. It has also been used as a serotonin receptor agonist to study its effects on the locomotion of zebrafish.

Acciones bioquímicas o fisiológicas

Quipazine belongs to the class of psychedelics and acts as a serotonin/5-hydroxytryptamine-2A/C receptor agonist. It also acts as an inhibitor of prolactin.

Pictogramas

Skull and crossbones
GHS06

Palabra de señalización

Danger

Frases de peligro

H301

Consejos de prudencia

P301 + P310 + P330

Clasificaciones de peligro

Acute Tox. 3 Oral

Código de clase de almacenamiento

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Dilip Kumar Pandey et al.
Pharmacology, biochemistry, and behavior, 94(3), 363-373 (2009-10-06)
Collective evidence suggests that inhibition of neuronal 5-hydroxytryptamine type 2A (5-HT(2A)) receptors contributes to the assuagement of depression-like behaviour in rodents. The present study evaluated the antidepressant-like effect of the 5-((4-benzo [alpha] isothiazol-3-yl) piperazin-1-yl) methyl)-6-chloroindolin-2-one (BIP-1), a compound having affinity
I D Knowles et al.
British journal of pharmacology, 128(3), 530-542 (1999-10-12)
1. The effects of injections i.c.v. of quipazine, (2 micromol kg-1) and 1-(2,5-di-methoxy-4-iodophenyl)-2-aminopropane (DOI; 2 micromol kg-1) on renal sympathetic and phrenic nerve activity, mean arterial blood pressure (MAP) and heart rate were investigated in alpha-chloralose anaesthetized rats pretreated with
Michele R Brumley et al.
Behavioural brain research, 229(1), 257-264 (2012-01-18)
Research has shown that sensory feedback modulates locomotor behavior in intact as well as spinal adult animals. Here we examined if locomotor activity ("stepping") in newborn rats is influenced by cutaneous and proprioceptive feedback. One-day-old rats were treated with the
Matthias D Ziegler et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(32), 10720-10726 (2010-08-13)
Spinal Wistar Hannover rats trained to step bipedally on a treadmill with manual assistance of the hindlimbs have been shown to improve their stepping ability. Given the improvement in motor performance with practice and the ability of the spinal cord
Grégoire Courtine et al.
Nature neuroscience, 12(10), 1333-1342 (2009-09-22)
After complete spinal cord transections that removed all supraspinal inputs in adult rats, combinations of serotonergic agonists and epidural electrical stimulation were able to acutely transform spinal networks from nonfunctional to highly functional and adaptive states as early as 1
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