PZ0195

CYP3cide

≥98% (HPLC)

• Sinónimos: 1-Methyl-3-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-4-[(3S)-3-piperidin-1-ylpyrrolidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine, PF-04981517
• Fórmula empírica (notación de Hill): C₂₆H₃₂N₈
• Número de CAS: 1390637-82-7
• Peso molecular: 456.59
• Número MDL: MFCD22417344
• Código UNSPSC: 12161501
• ID de la sustancia en PubChem: 329823769
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to beige
• solubilidad: DMSO: >10 mg/mL (warmed)
• temp. de almacenamiento: room temp
• cadena SMILES: Cc1ccc(cc1)-c2c(cnn2C)-c3nn(C)c4ncnc(N5CC[C@@H](C5)N6CCCCC6)c34
• InChI: 1S/C26H32N8/c1-18-7-9-19(10-8-18)24-21(15-29-31(24)2)23-22-25(32(3)30-23)27-17-28-26(22)34-14-11-20(16-34)33-12-5-4-6-13-33/h7-10,15,17,20H,4-6,11-14,16H2,1-3H3/t20-/m0/s1
• Clave InChI: WDWIMDKOXZZYHH-FQEVSTJZSA-N

Descripción

Acciones bioquímicas o fisiológicas

CYP3cide is a mechanism-based inhibitor of cytochrome P4503A4 that can be used to distinguish the contributions of CYP3A4 versus CYP3A5 on drug metabolism. The IC₅₀ values for inhibition of Midazolam 1′-Hydroxylase activity of recombinant CYP3A4 and CYP3A5 by CYP3cide are 0.3 and 17 mM, respectively.

CYP3cide is a mechanism-based inhibitor of cytochrome P4503A4.

Características y beneficios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Información legal

Sold for research purposes under agreement from Pfizer Inc.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable