PZ0158

PF 3845 hydrate

≥98% (HPLC)

• Sinónimos: N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide hydrate
• Fórmula empírica (notación de Hill): C₂₄H₂₃F₃N₄O₂ · xH₂O
• Número de CAS: 1196109-52-0
• Peso molecular: 456.46 (anhydrous basis)
• Número MDL: MFCD21365072
• Código UNSPSC: 51111800
• ID de la sustancia en PubChem: 329823740
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated
• color: white to tan
• solubilidad: DMSO: ≥45 mg/mL
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O.FC(F)(F)c1ccc(Oc2cccc(CC3CCN(CC3)C(=O)Nc4cccnc4)c2)nc1
• InChI: 1S/C24H23F3N4O2.H2O/c25-24(26,27)19-6-7-22(29-15-19)33-21-5-1-3-18(14-21)13-17-8-11-31(12-9-17)23(32)30-20-4-2-10-28-16-20;/h1-7,10,14-17H,8-9,11-13H2,(H,30,32);1H2
• Clave InChI: CVQMBUCCSAKASE-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

PF 3845 hydrate is a potent, irreversible FAAH inhibitor

PF 3845 is a potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. The endocannabinoid system is a target for therapeutic pain relief. PF-3845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It high selectivity over other enzymes including FAAH-2. In mouse studies, PF-3845 has been shown to raise brain anandamide levels for up to 24 hr; and in a rat model it produced significant reduction of inflammatory pain..

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable