PRS4059

Anti-PDL-1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-B7-H1, Anti-CD274 molecule, Anti-Cardif, Anti-IPS-1, Anti-Programmed cell death 1 ligand-1
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: predicted mol wt 32 kDa
• reactividad de especies: human, rat, mouse
• técnicas: flow cytometry: suitable; immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• Nº de acceso UniProt: Q9NZQ7
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... CD274(29126)

Descripción

Descripción general

PDL-1 (programmed cell death 1 ligand 1) is a cell surface protein, that is also known as B7-H1 (B7 homolog 1), coded by CD274 (cluster of differentiation 274) gene. It is located on chromosome 9p24.1. It is present on placental cells, vascular endothelial cells, liver cells, epithelial cells, mesenchymal stem cells, B cells, T cells, dendritic cells and macrophages. It is also expressed in various tumor types like melanoma, glioblastoma, cancers in the lung, kidney, head, neck, stomach, colon, pancreas, breast, cervix and ovary.

Inmunógeno

17 amino acid peptide from near the center of human PDL-1.

Acciones bioquímicas o fisiológicas

PDL-1 (programmed cell death 1 ligand 1) helps to clear sudden HPV (human papilloma virus) infections. It prevents the multiplication and adherence of T-cell and production of cytokine. It also controls the activities of T-cells in peripheral tissues.

Ligadura / enlace

The action of this antibody can be blocked using blocking peptide SBP4059.

Forma física

Solution in phosphate buffered saline containing 0.02% sodium azide

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable