PRS3363

Anti-ST2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-Interleukin 1 receptor-like 1
• Número MDL: MFCD01633642
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• reactividad de especies: mouse, human
• técnicas: immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• Nº de acceso UniProt: P14719
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: mouse ... Il1rl1(17082)

Descripción

Descripción general

ST2 (suppression of tumorigenicity) belongs to the IL-1 family of cytokines. It is also known as IL-33 (interleukin 33) and IL1RL1 (interleukin 1 receptor like 1). It is expressed in macrophages and various inflammatory cells like T helper 2 (Th2), mast cells, basophils and eosinophils. It is mapped to chromosome 2q12.

Inmunógeno

a synthetic peptide corresponding to 16 amino acids at the amino-terminus of mouse ST2. This peptide is common to all three known ST2 isoforms.

Aplicación

Anti-ST2 has been used in immunohistochemistry, western blottingand immunofluorescence staining.

Acciones bioquímicas o fisiológicas

ST2 (suppression of tumorigenicity) participates in pathophysiology of several diseases like asthma, arthritis, obesity and atherosclerosis. It works as a mitogen in eosinophils, fibrocytes, endothelial cells. It helps in the migration of Th2 lymphocytes, fibrocytes and endothelial cells, and disturbs the incursion and metastasis of breast tumor.

Ligadura / enlace

The action of this antibody can be blocked using blocking peptide SBP3363.

Forma física

Solution in phosphate buffered saline containing 0.02% sodium azide

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable