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P9107

Sigma-Aldrich

Anti-Potassium Channel Kv1.3 (Charybdotoxin-Sensitive Voltage-Dependent Potassium Channel, HLK3) antibody produced in rabbit

IgG fraction of antiserum, lyophilized powder

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About This Item

Número MDL:
MFCD02097210
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

100

conjugado

unconjugated

forma del anticuerpo

IgG fraction of antiserum

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

lyophilized powder

reactividad de especies

rat, mouse, human

técnicas

immunocytochemistry: 1:50 using cells permeabilized with 0.2% Triton X-100
western blot (chemiluminescent): 1:100

Nº de acceso UniProt

P22001

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... KCNA3(3738)
mouse ... Kcna3(16491)
rat ... Kcna3(29731)

Especificidad

Recognizes a full-length Kv1.3 protein. Does not cross-react with other potassium channel antigens.

Inmunógeno

highly purified GST fusion protein from the C-terminal of human potassium channel Kv1.3. The protein corresponds to amino acids 471-523.

Aplicación

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Forma física

Lyophilized at ~1 mg/ml from phosphate buffered saline, pH 7.4, containing 5% sucrose, 1% bovine serum albumin, and 0.025% sodium azide.

Nota de preparación

Protein A purified.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Y C Cai et al.
DNA and cell biology, 11(2), 163-172 (1992-03-01)
Voltage-gated potassium channels play important functional roles in the development and maintenance of human lymphocyte functions. One such channel, known as the type n channel, has been well defined in human T cells and exhibits unique functional properties that distinguish
B Attali et al.
The Journal of biological chemistry, 267(12), 8650-8657 (1992-04-25)
Low stringency screening of a Jurkat cDNA library with a rat brain K+ channel (RCK1) probe has resulted in the isolation of HLK3, a voltage-gated K+ channel. In Xenopus oocytes, the HLK3 clone directs the expression of a rapidly activating
Stella A Nicolaou et al.
Journal of immunology (Baltimore, Md. : 1950), 183(10), 6296-6302 (2009-10-21)
The immunological synapse (IS), a highly organized structure that forms at the point of contact between a T cell and an APC, is essential for the proper development of signaling events, including the Ca(2+) response. Kv1.3 channels control Ca(2+) homeostasis
Yi-Je Chen et al.
PloS one, 8(11), e81006-e81006 (2013-12-07)
Allograft vasculopathy (AV) remains one of the major challenges to the long-term functioning of solid organ transplants. Although its exact pathogenesis remains unclear, AV is characterized by both fibromuscular proliferation and infiltration of CD4(+) memory T cells. We here tested

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