P8953

Platelet-Derived Growth Factor from porcine platelets

≥97% (SDS-PAGE and N-terminal analysis), lyophilized powder, suitable for cell culture

• Sinónimos: PDGF
• Número MDL: MFCD00166903
• Código UNSPSC: 12352202
• NACRES: NA.77

Propiedades

• Nombre del producto: Platelet-Derived Growth Factor from porcine platelets, PDGF, lyophilized powder, suitable for cell culture
• origen biológico: Porcine
• Nivel de calidad: 200
• Ensayo: ≥97% (SDS-PAGE and N-terminal analysis)
• Formulario: lyophilized powder
• potencia: 39.00 ng/mL EC₅₀
• calidad: endotoxin tested
• mol peso: glycoprotein 38 kDa
• envase: pkg of 5 μg
• condiciones de almacenamiento: avoid repeated freeze/thaw cycles
• técnicas: cell culture | mammalian: suitable
• impurezas: ≤1 EU/μg
• color: white
• Nº de acceso UniProt: P20034
• temp. de almacenamiento: −20°C
• Información sobre el gen: pig ... PDGFB(100626465)

Descripción

Aplicación

PDGF elicits multifunctional actions with a variety of cells, including mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts.

Acciones bioquímicas o fisiológicas

The principal mitogen found in mammalian serum, released from platelets during clot formation. Elicits mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts. Mitogenic for dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells and chondrocytes. Appears to interact with transforming growth factor-β1 in accelerating wound healing. However, platelet-derived growth factor (PDGF) may also be pathogenic in arteriosclerosis and neoplasia.

Forma física

Lyophilized from a 0.2 μm filtered solution in 40% acetonitrile and 0.1% trifluoroacetic acid, pH 2.0.

Nota de análisis

The mitogenic activity is tested in culture using Swiss 3T3 cells or NR6-3T3 fibroblasts.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)