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P8511

Sigma-Aldrich

trans-2-Phenylcyclopropylamine hydrochloride

Sinónimos:

Tranylcypromine

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About This Item

Fórmula lineal:
C6H5C3H4NH2·HCl
Número de CAS:
1986-47-6
Peso molecular:
169.65
Número MDL:
MFCD00063602
Código UNSPSC:
12352116
ID de la sustancia en PubChem:
24278187
NACRES:
NA.77

origen biológico

synthetic (organic)

Análisis

≥97% (TLC)

formulario

powder

mp

162-169 °C (lit.)

solubilidad

ethanol: 50 mg/mL, clear to slightly hazy

temp. de almacenamiento

2-8°C

cadena SMILES

Cl.N[C@@H]1C[C@H]1c2ccccc2

InChI

1S/C9H11N.ClH/c10-9-6-8(9)7-4-2-1-3-5-7;/h1-5,8-9H,6,10H2;1H/t8-,9+;/m0./s1

Clave InChI

ZPEFMSTTZXJOTM-OULXEKPRSA-N

Información sobre el gen

human ... MAOA(4128) , MAOB(4129)

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Acciones bioquímicas o fisiológicas

Non-selective MAO-A/B inhibitor.

Características y beneficios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogramas

Skull and crossbones
GHS06

Palabra de señalización

Danger

Frases de peligro

H301

Clasificaciones de peligro

Acute Tox. 3 Oral

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Navneet Goyal et al.
Journal of cancer metastasis and treatment, 7 (2021-11-02)
In this study, our goal was to study the inhibition of nicotine metabolism by P450 2A6, as a means for reduction in tobacco use and consequently the prevention of smoking-related cancers. Nicotine, a phytochemical, is an addictive stimulant, responsible for
Jesse H Arbuckle et al.
mBio, 5(1), e01027-e01013 (2014-01-16)
Upon infection, the genome of herpes simplex virus is rapidly incorporated into nucleosomes displaying histone modifications characteristic of heterochromatic structures. The initiation of infection requires complex viral-cellular interactions that ultimately circumvent this repression by utilizing host cell enzymes to remove
Martin Engel et al.
Journal of neurochemistry, 149(4), 535-550 (2018-12-29)
Targeting epigenetic mechanisms has shown promise against several cancers but has so far been unsuccessful against glioblastoma (GBM). Altered histone 3 lysine 4 methylation and increased lysine-specific histone demethylase 1A (LSD1) expression in GBM tumours nonetheless suggest that epigenetic mechanisms
Kaisa A Salminen et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(12), 1891-1904 (2015-09-25)
The cytochrome P450 2C19 (CYP2C19) enzyme plays an important role in the metabolism of many commonly used drugs. Relatively little is known about CYP2C19 inhibitors, including compounds of natural origin, which could inhibit CYP2C19, potentially causing clinically relevant metabolism-based drug
M Angeles Rabadan et al.
Nature communications, 13(1), 3340-3340 (2022-06-11)
Advances in 3D neuronal cultures, such as brain spheroids and organoids, are allowing unprecedented in vitro access to some of the molecular, cellular and developmental mechanisms underlying brain diseases. However, their efficacy in recapitulating brain network properties that encode brain
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