P5515

Prostaglandin E₁

≥98% (HPLC), powder, vasodilator 

• Sinónimos: (11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid, Alprostadil, PGE₁
• Fórmula empírica (notación de Hill): C₂₀H₃₄O₅
• Número de CAS: 745-65-3
• Peso molecular: 354.48
• Beilstein: 5294062
• Número CE: 212-017-2
• Número MDL: MFCD00077860
• Código UNSPSC: 12352211
• eCl@ss: 42020658
• ID de la sustancia en PubChem: 57654538
• NACRES: NA.77

Propiedades

• Nombre del producto: Prostaglandin E₁, ≥98% (HPLC), synthetic
• origen biológico: synthetic
• Nivel de calidad: 200
• Ensayo: ≥98% (HPLC)
• Formulario: (powder to crystals)
• solubilidad: ethanol: 5 mg/mL
• temp. de almacenamiento: −20°C
• cadena SMILES: O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1
• InChI: 1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
• Clave InChI: GMVPRGQOIOIIMI-DWKJAMRDSA-N
• Información sobre el gen: human ... PTGER1(5731) , PTGER2(5732) , PTGIR(5739) ; mouse ... Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219)

Descripción

Aplicación

Prostaglandin E1 has been used:

• as a platelet inhibitor to analyse its effect on autophagy
• in platelet adhesion assay
• to investigate its effect on cAMP production in thyroid glands of normal and growth-retarded mouse in vitro.

Acciones bioquímicas o fisiológicas

Prostaglandin E1 (PGE1) is a hormone synthesized from dihomo-γ-linolenic acid (DGLA) by the action of enzyme prostaglandin synthase. It is a vasodilator and activates adenylate cyclase. It is majorly present in human semen and is a potent platelet aggregation inhibitor. PGE1 infusions is effective in treating limb ischemia and peripheral vascular disease. It is unstable and is hydrolyzed to PGA1 in the lungs. Nanoparticle encapsulation of PGE1 is essential for its delivery at the vascular injury site. It elicits vasodilator effects on the retinal artery and vein in central retinal artery occlusion (CRAO). PGE1 and its synthetic analog misoprostol interact with E-prostanoid receptor 4 (EP4) and elicits protection in chronic myelogenous leukemia (CML).

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H301
• Consejos de prudencia: P301 + P310 + P330
• Clasificaciones de peligro: Acute Tox. 3 Oral
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves