P1247
Anti-Peroxiredoxin 3 antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Sinónimos:
Anti-AOP1, Anti-Antioxidant Protein 1, Anti-PRDX3
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About This Item
Productos recomendados
origen biológico
rabbit
conjugado
unconjugated
forma del anticuerpo
IgG fraction of antiserum
tipo de anticuerpo
primary antibodies
clon
polyclonal
formulario
buffered aqueous solution
mol peso
antigen ~25 kDa
reactividad de especies
human
técnicas
microarray: suitable
western blot: 1:4,000-1:8,000 using HeLa cell mitochondria extracts
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... PRDX3(10935)
Descripción general
PRDX3, also known as antioxidant protein 1 (AOP1), MER-5, or SP-22, belongs to a family of proteins termed peroxiredoxins (Prx). It is a mitochondrial protein.
The PRDX3 gene is located on the human chromosome at 10q26.11.
Especificidad
Whole antiserum is purified to provide an IgG fraction of antiserum Anti-Peroxiredoxin 3 recognizes human PRDX3.
Inmunógeno
synthetic peptide corresponding to amino acids 241-256 of human peroxiredoxin 3, conjugated to KLH via an N-terminal lysine residue.
Aplicación
Anti-Peroxiredoxin 3 antibody produced in rabbit has been used in western blotting.
Acciones bioquímicas o fisiológicas
Peroxiredoxin 3 (PRDX3) catalyzes the reduction of peroxides in the presence of thioredoxin. The Prx family has been identified in association with a variety of diverse cellular functions including growth control, proliferation, differentiation, and in the response to oxidative stress. PRDX3 is required to maintain normal mitochondrial function through direct activation by c-Myc, which may explain its overexpression during neoplastic transformation.
Forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Almacenamiento y estabilidad
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in frost-free freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
11 - Combustible Solids
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria
Chang TM, et al.
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Cervical cancer (CC) is the third most common malignancy in women globally, and persistent infection with the oncogenic human papillomaviruses (HPV) is recognized as the major risk factor. The pathogenesis of CC relies on the interplay between the tumorigenic properties
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Peroxiredoxin 3 levels regulate a mitochondrial redox setpoint in malignant mesothelioma cells
Cunniff B, et al.
Redox Biology, 3(40), 79-87 (2014)
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