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O9265

Sigma-Aldrich

Osthole

Sinónimos:

7-Methoxy-8-(3-methyl-2-butenyl)coumarin, 7-Methoxy-8-isopentenylcoumarin, Osthol

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About This Item

Fórmula empírica (notación de Hill):
C15H16O3
Número de CAS:
484-12-8
Peso molecular:
244.29
Número MDL:
MFCD00076049
Código UNSPSC:
12352205
ID de la sustancia en PubChem:
329818938
NACRES:
NA.25

Ensayo

≥95% (HPLC)

Formulario

powder

color

white

solubilidad

methanol: soluble 10 mg/mL, clear, colorless

aplicaciones

metabolomics
vitamins, nutraceuticals, and natural products

temp. de almacenamiento

room temp

cadena SMILES

COc1ccc2C=CC(=O)Oc2c1C\C=C(\C)C

InChI

1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3

Clave InChI

MBRLOUHOWLUMFF-UHFFFAOYSA-N

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Acciones bioquímicas o fisiológicas

Active constituent of Cnidium monnieri, a traditional Chinese medicine used for its anti-inflammatory, analgesic, and anti-lipedemic activities. Dramatically decreased lipid accumulation in a quail model. Its neuroprotective effect on MPP(+)-induced cytotoxicity in PC12 cells supports the use of osthole as a therapeutic agent for the treatment of neurodegenerative disorders. Suppression of fatty acid synthase expression in HER2-overexpressing breast cancer cells indicates osthole as a promising agent for chemotherapy.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
SLCJ5069
SLCF3027
SLCF3026
SLCD3695
SLBV2162

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Sigma-Aldrich

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Yue-fei Zhou et al.
The Journal of surgical research, 185(2), 805-814 (2013-08-01)
Osthole, the main bioactive compounds isolated from the traditional Chinese medical herb broad Cnidium monnieri (L.) cusson, has been shown to exert spectrum of pharmacologic activities. The aim of this study was to investigate the potential neuroprotective effects of osthole
Wonhyoung Park et al.
Nutrients, 11(11) (2019-11-17)
Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death in women. Although, recently, the number of pathological studies of breast cancer have increased, it is necessary to identify a novel compound that targets
Ola D Alabi et al.
Life sciences, 102(2), 105-110 (2014-03-25)
Osthole, a coumarin derivative, has been used in Chinese medicine and studies have suggested a potential use in treatment of diabetes and cancers. Therefore, we investigated the effects of osthole and other coumarins on GLUT1 activity in two cell lines
Natalia K Kordulewska et al.
Nutrients, 13(1) (2021-01-06)
Lipopolysaccharydes (LPS) are responsible for the intestinal inflammatory reaction, as they may disrupt tight junctions and induce cytokines (CKs) secretion. Osthole has a wide spectrum of pharmacological effects, thus its anti-inflammatory potential in the LPS-treated Caco-2 cell line as well
Jian Zhou et al.
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 35(5), 561-566 (2013-11-05)
To investigate the effect of osthole on bone metabolism in rat femoral tissues in vitro. The rat femoral tissues were isolated in vitro. The optimal concentrations of ostehole (1×10(-5) mol/L) and estradiol (1×10(-8) mol/L) (the positive control) were selected by

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Fatty Acid Synthesis and Metabolism in Cancer Cells

Information on fatty acid synthesis and metabolism in cancer cells. Learn how proliferatively active cells require fatty acids for functions such as membrane generation, protein modification, and bioenergetic requirements. These fatty acids are derived either from dietary sources or are synthesized by the cell.

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