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Merck

N6505

Sigma-Aldrich

ββ-Nicotinamida adenina dinucleótico 2′-fosfato reducido tetrasodium salt hydrate

≥95% (HPLC)

Sinónimos:

ββ-NADPH, 2′-NADPH hydrate, Coenzima II reducida tetrasodium salt, Dihidronicotinamida adenina dinucleótido fosfato tetrasodium salt, NADPH Na4, Nucleótido de trifosfopiridina reducido tetrasodium salt, TPNH2 Na4

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About This Item

Fórmula empírica (notación de Hill):
C21H26N7Na4O17P3 · xH2O
Número de CAS:
Peso molecular:
833.35 (anhydrous basis)
Número MDL:
Código UNSPSC:
41106305
ID de la sustancia en PubChem:
NACRES:
NA.51

Nivel de calidad

Análisis

≥95% (HPLC)
≥95% (spectrophotometric assay)

formulario

powder

temp. de almacenamiento

−20°C

cadena SMILES

[Na+].[Na+].[Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@H]2O[C@@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](OP([O-])([O-])=O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@H](O)[C@@H]2O

InChI

1S/C21H30N7O17P3.4Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;;;;/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35);;;;/q;4*+1/p-4/t10-,11+,13-,14+,15-,16+,20-,21+;;;;/m0..../s1

Clave InChI

WYWWVJHQDVCHKF-MPUNMZHWSA-J

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Aplicación

β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP).

Acciones bioquímicas o fisiológicas

El NADPH es un donante de electrones y un cofactor de muchas enzimas rédox, entre ellas la óxido nítrico sintetasa.

Nota de preparación

Enzymatically reduced.

Otras notas

Envasado en función del peso sólido.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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The hypocretin neurons have been implicated in regulating sleep-wake states as they are lost in patients with the sleep disorder narcolepsy. Hypocretin (HCRT) neurons are located only in the perifornical region of the posterior hypothalamus and heavily innervate pontine brainstem
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Journal of dairy science, 94(6), 2850-2858 (2011-05-25)
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The incoming signals from injured sensory neurons upon peripheral inflammation are processed in the dorsal horn of spinal cord, where glial cells accumulate and play a critical role in initiating allodynia (increased pain in response to light-touch). However, how painful
Kevin P Grace et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(5), 1622-1633 (2012-02-04)
Serotonin type 1A (5-HT(1A)) receptor-responsive neurons in the pedunculopontine tegmental nucleus (PPTn) become maximally active immediately before and during rapid eye movement (REM) sleep. A prevailing model of REM sleep generation indicates that activation of such neurons contributes significantly to
Jagdish K Racha et al.
Drug metabolism and pharmacokinetics, 18(2), 128-138 (2004-12-25)
The CYP3A4 enzyme is known for its atypical inhibition kinetics; ligand inhibition can differ depending upon the probe drug used. A high throughput-LCMS/MS CYP3A4 inhibition assay with four substrate drugs was developed to minimize the potential oversight of CYP3A4 inhibition.

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