N3136

Naltrexone hydrochloride

≥99% (HPLC), powder, opioid receptor antagonist

• Sinónimos: Naltrexone HCl
• Fórmula empírica (notación de Hill): C₂₀H₂₃NO₄ · HCl
• Número de CAS: 16676-29-2
• Peso molecular: 377.86
• Beilstein: 3580333
• Número CE: 240-723-0
• Número MDL: MFCD00069324
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24278051
• NACRES: NA.77

Propiedades

• product name: Naltrexone hydrochloride,
• formulario: powder
• emisor: Novartis
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC6CC6
• InChI: 1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1
• Clave InChI: RHBRMCOKKKZVRY-ITLPAZOVSA-N
• Información sobre el gen: human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988) , OPRS1(10280)

Descripción

Aplicación

Naltrexone hydrochloride has been used:

• as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model
• to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model
• in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22

Acciones bioquímicas o fisiológicas

Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.

Características y beneficios

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves