N1019

(−)-Nicotine hemisulfate salt

≥95% (TLC), ~35 % (w/v) in H₂O (based on free base)

• Sinónimos: (−)-1-Methyl-2-(3-pyridyl)pyrrolidine
• Fórmula lineal: (C₁₀H₁₄N₂)₂ · H₂SO₄
• Número de CAS: 65-30-5
• Peso molecular: 422.54
• Número MDL: MFCD00148918
• Código UNSPSC: 12352210
• ID de la sustancia en PubChem: 24897454
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (TLC)
• Formulario: liquid
• concentración: ~35 % (w/v) in H₂O (based on free base)
• color: dark brown
• cadena SMILES: OS(O)(=O)=O.CN1CCC[C@H]1c2cccnc2.CN3CCC[C@H]3c4cccnc4
• InChI: 1S/2C10H14N2.H2O4S/c2*1-12-7-3-5-10(12)9-4-2-6-11-8-9;1-5(2,3)4/h2*2,4,6,8,10H,3,5,7H2,1H3;(H2,1,2,3,4)/t2*10-;/m00./s1
• Clave InChI: IECQULMJVNSKDB-RCWTXCDDSA-N
• Información sobre el gen: human ... CHRNA4(1137) , CHRNB2(1141)

Descripción

Descripción general

Nicotine is found in the leaves of Nicotiana species. It binds to nicotinic acetylcholine receptors and inhibits endogenous neurotransmitters. Nicotine is associated with lung cancer development and reduces the efficiency of chemotherapeutic agents. It is used to treat Alzheimer′s and Parkinson′s disease.

Aplicación

(−)-Nicotine hemisulfate salt has been used to study the influence of nicotine on the severity of choroidal neovascularization (CNV). It also has been used as a natural nectar alkaloid to study the effect of self-medication in bumblebees.

Acciones bioquímicas o fisiológicas

Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.

Calidad

Mixture of nicotine base and nicotine sulfate.

Precaución

Shelf-life of the solution as supplied is at least six years when stored at room temperature.

Información de seguridad

• Pictogramas: GHS06,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H301,H310 + H330,H411
• Consejos de prudencia: P260 - P262 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Clasificaciones de peligro: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3