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MAK152

Sigma-Aldrich

Colorimetric Sphingomyelinase Assay Kit

sufficient for 200 colorimetric tests

Sinónimos:

Neutral Sphingomyelinase Assay Kit

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About This Item

Código UNSPSC:
12161503
NACRES:
NA.84

uso

sufficient for 200 colorimetric tests

método de detección

colorimetric

enfermedades relevantes

rheumatological diseases; cancer

temp. de almacenamiento

−20°C

Información sobre el gen

human ... SMPD2(6610) , SMPD3(55512) , SMPD4(55627)
mouse ... SMPD2(20598) , SMPD3(58994) , SMPD4(77626)
rat ... SMPD2(83537) , SMPD3(94338) , SMPD4(303790)

Descripción general

Sphingomyelinase (SMase), or sphingomyelin phosphodiesterase, catalyzes the hydrolytic cleavage of sphingolipid to phosphocholine and ceramide, a second messenger involved in multiple cellular responses including the cellular response to stress. There are at least 5 types of SMases identified which are classified according to their cation dependence, cellular location, and pH optima for activity and include the acidic and neutral sphingomyelinase. Neutral SMases, along with the acidic SMases, are thought to be major contributors to the production of ceramide in response to cellular stress.

Características y beneficios

Compatible with high-throughput handling systems.

Idoneidad

This kit is suitable for the detection of sphingomyelinase activity in a variety of samples such as blood and cell extracts or for screening sphingomyelinase inhibitors and activators.

Principio

The Sphingomyelinase Assay Kit provides a simple and direct procedure for measuring neutral SMase activity in a variety of samples such as blood or cell extracts, or for screening SMase activators and inhibitors. SMase activity is determined by a coupled enzyme assay, which results in a colorimetric (655 nm) product proportional to the SMase activity present.

Palabra de señalización

Danger

Frases de peligro

H317,H318,H334,H410

Clasificaciones de peligro

Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Sens. 1

Código de clase de almacenamiento

10 - Combustible liquids

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Certificados de análisis (COA)

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Javad Habibi et al.
Journal of molecular and cellular cardiology, 167, 32-39 (2022-03-26)
Sphingomyelinases ensure ceramide production and play an integral role in cell turnover, inward budding of vesicles and outward release of exosomes. Recent data indicate a unique role for neutral sphingomyelinase (nSMase) in the control of ceramide-dependent exosome release and inflammatory

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