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M7695

Sigma-Aldrich

Anti-Munc-18-3 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-MUNC18C, Anti-PSP, Anti-Syntaxin Binding Protein 3 (STXBP3), Anti-UNC-18C

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

mol peso

antigen ~66 kDa

reactividad de especies

rat, mouse, human

técnicas

western blot: 0.75-1.5 μg/mL using mouse brain extract (S1 fraction)

Nº de acceso UniProt

O00186

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... STXBP3(6814)
mouse ... Stxbp3a(20912)
rat ... Stxbp3(114095)

Descripción general

Mammalian uncoordinated-18-3 (Munc-18-3) (also known as Munc-18c, syntaxin-binding protein 3, STXBP3) is ubiquitously expressed.

Inmunógeno

synthetic peptide corresponding to amino acids 578-592 located at the C-terminus of mouse Munc-18-3, conjugated to KLH. This sequence is highly conserved (~90% identity) in human and rat Munc-18-3.

Aplicación

Anti-Munc-18-3 antibody produced in rabbit has been used in immunohistochemistry and western blotting

Acciones bioquímicas o fisiológicas

Mammalian uncoordinated-18-3 (Munc-18-3) expressed in 3T3-L1 adipocytes has been shown to interact with syntaxin 2 and 4 and to inhibit the binding of syntaxin-4 to vesicle associated membrane protein 2 (VAMP2). Munc-18c has been suggested to play a role in the docking/fusion of glucose transporter type 4 (GLUT4)-containing vesicles with the cell membrane of 3T3-L1 adipocytes. Heterozygous knock-out of the Munc-18c gene in mice impairs insulin-stimulated GLUT4 translocation in skeletal muscle and increases the susceptibility for severe glucose intolerance.
Munc-18-3 has a role in glucose metabolism and is involved in controlling the translocation of glucose transporter type 4 (GLUT4) in adipocytes.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
057K4875

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Munc18c heterozygous knockout mice display increased susceptibility for severe glucose intolerance
Oh E, et al.
Diabetes, 54(3), 638-647 (2005)
Protein expression of PKCZ (Protein Kinase C Zeta), Munc18c, and Syntaxin-4 in the insulin pathway in endometria of patients with polycystic ovary syndrome (PCOS
<BIG>Rivero R, et al</BIG>
Reproductive Biology and Endocrinology, 10, 17-17 (2012)
Lourdes Garrido-Sanchez et al.
PloS one, 8(5), e63937-e63937 (2013-05-24)
Munc18c is associated with glucose metabolism and could play a relevant role in obesity. However, little is known about the regulation of Munc18c expression. We analyzed Munc18c gene expression in human visceral (VAT) and subcutaneous (SAT) adipose tissue and its
Rodrigo Rivero et al.
Reproductive biology and endocrinology : RB&E, 10, 17-17 (2012-03-07)
Polycystic Ovary Syndrome (PCOS) is an endocrine-metabolic disorder commonly associated with insulin resistance (IR). Previous studies indicate about the expression of molecules involved in the insulin pathway in endometria of women with PCOS-IR. Therefore, the aim of the present study
Anatoly Uzdensky et al.
Molecular neurobiology, 54(6), 4172-4188 (2016-06-22)
After ischemic stroke, cell damage propagates from infarct core to surrounding tissues (penumbra). To reveal proteins involved in neurodegeneration and neuroprotection in penumbra, we studied protein expression changes in 2-mm ring around the core of photothrombotic infarct induced in the

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