M6133

7-Methylguanosine 5′-triphosphate sodium salt

≥85% (HPLC)

• Sinónimos: m7GTP
• Fórmula empírica (notación de Hill): C₁₁H₁₈N₅O₁₄P₃ · xNa⁺
• Número de CAS: 104809-18-9
• Peso molecular: 537.21 (free acid basis)
• Número MDL: MFCD00063376
• Código UNSPSC: 41106305
• ID de la sustancia en PubChem: 24897079
• NACRES: NA.51

Propiedades

• origen biológico: natural (inorganic)
• Análisis: ≥85% (HPLC)
• formulario: powder
• temp. de almacenamiento: −20°C
• cadena SMILES: [Na+].C[n+]1cn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]2O)c3N=C(N)NC([O-])c13
• InChI: 1S/C11H20N5O14P3.Na/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22;/h3-4,6-7,9-10,17-18H,2H2,1H3,(H,23,24)(H,25,26)(H3,12,13,14)(H2,20,21,22);/q;+1/p-1/t4-,6-,7-,9?,10-;/m1./s1
• Clave InChI: FSMRTZAMTMQMEF-OCMBMSOASA-M

Descripción

Descripción general

7-Methylguanosine 5′-triphosphate is a mRNA cap structural analog.

Aplicación

7-Methylguanosine 5′-triphosphate (m7GTP) is use to study the structures and mechanisms of eukaryotic cellular mRNA caps in the context of mRNA involvement in protein synthesis. m7GTP may be used to create affinity media for capture and purification of molecules such as eukaryotic initiation factor eIF4E.

7-Methylguanosine 5′-triphosphate sodium salt has been used to test its affinity towards Poly(A)-specific ribonuclease (PARN) polypeptides using fluorescence titrations. It has also been used in crystallization along with gemin5 fragment (G5N) and DM15 region of human La-related 15 protein 1 ( LARP1).

Acciones bioquímicas o fisiológicas

7-Methylguanosine 5′-triphosphate (m7GTP) inhibits in vitro protein synthesis by binding to translation initiation complexes. m7GTP is useful to study the structures and mechanisms of eukaryotic cellular mRNA caps in the context of mRNA involvement in protein synthesis. m7GTP has a high affinity for eukaryotic initiation factor eIF4E and may be used to create affinity media for their capture and purification.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves