M5750

Menadione sodium bisulfite

≥95% (TLC)

• Sinónimos: 2-Methyl-1,4-naphthoquinone sodium bisulfite
• Fórmula empírica (notación de Hill): C₁₁H₉NaO₅S
• Número de CAS: 130-37-0
• Peso molecular: 276.24
• Número CE: 204-987-0
• Número MDL: MFCD00051456
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24897038
• NACRES: NA.77

Propiedades

• origen biológico: synthetic
• Nivel de calidad: 200
• Ensayo: ≥95% (TLC)
• Formulario: powder
• color: white to off-white
• solubilidad: H₂O: ≥50 mg/mL, clear, colorless to faintly yellow
• aplicaciones: cell analysis
• emisor: Eli Lilly
• temp. de almacenamiento: −20°C
• cadena SMILES: [Na+].CC1(CC(=O)c2ccccc2C1=O)S([O-])(=O)=O
• InChI: 1S/C11H10O5S.Na/c1-11(17(14,15)16)6-9(12)7-4-2-3-5-8(7)10(11)13;/h2-5H,6H2,1H3,(H,14,15,16);/q;+1/p-1
• Clave InChI: XDPFHGWVCTXHDX-UHFFFAOYSA-M

Descripción

Aplicación

Menadione sodium bisulfite has been used:

• as a priming agent in tomato for improving salt tolerance
• to induce reactive oxygen species (ROS) in human lung epithelium BEAS-2B microtissues
• to induce endogenous superoxide production in mouse C17.2 neural stem cells

Acciones bioquímicas o fisiológicas

Menadione sodium bisulfite is a water-soluble form of menadione, which belongs to the Vitamin K class of compounds. These are necessary for the biosynthesis of prothrombin and other blood clotting factors. Menadione is a prothrombogenic compound and is used as a model quinone in cell culture and in vivo investigations.

Menadione has been shown to affect gap-junctional intercellular communication by mediation of tyrosine phosphorylation. Menadione has demonstrated cytotoxic activity against a variety of cell lines and can induce apoptosis in cultured cells, such as osteoclasts and osteoblasts, via elevation of peroxide and superoxide radical levels.

An HPLC method for detection of menadione sodium bisulfite in multivitamin formulations has been published. A chemiluminescence assay for menadione sodium bisulfite in pharmaceutical preparations and biological fluids has been reported.

Características y beneficios

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Otras notas

Water soluble vitamin K₃.

Información de seguridad

• Pictogramas: GHS07,GHS09
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H410
• Consejos de prudencia: P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Clasificaciones de peligro: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves