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M5693

MEDICA 16

Name: MEDICA 16
Brand: SIGMA

powder, ≥97% (HPLC)

Sinónimos:

3,3,14,14-Tetramethylhexadecanedioic acid

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About This Item

Fórmula empírica (notación de Hill):

C₂₀H₃₈O₄

Número de CAS:

87272-20-6

Peso molecular:

342.51

Número MDL:

MFCD00797684

Código UNSPSC:

12352200

ID de la sustancia en PubChem:

24724539

NACRES:

NA.77

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Sigma-Aldrich

D5628

Digitonina

Análisis

≥97% (HPLC)

formulario

powder

color

white to beige

mp

154-159 °C

solubilidad

DMSO: 10 mg/mL, clear

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

cadena SMILES

CC(C)(CCCCCCCCCCC(C)(C)CC(O)=O)CC(O)=O

InChI

1S/C20H38O4/c1-19(2,15-17(21)22)13-11-9-7-5-6-8-10-12-14-20(3,4)16-18(23)24/h5-16H2,1-4H3,(H,21,22)(H,23,24)

Clave InChI

HYSMCRNFENOHJH-UHFFFAOYSA-N

Acciones bioquímicas o fisiológicas

MEDICA 16 is an ATP-citrate lyase inhibitor and potent triacylglycerol-lowering agent. The product is hypolipidemic, antidiabetic, and shows reduced adiposity.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Adipose tissue sensitization to insulin induced by troglitazone and MEDICA 16 in obese Zucker rats in vivo.

Bella Kalderon et al.

American journal of physiology. Endocrinology and metabolism, 284(4), E795-E803 (2002-12-19)

The putative role played by insulin sensitizers in modulating adipose tissue lipolysis in the fasting state was evaluated in obese conscious Zucker rats treated with troglitazone or beta,beta'-tetramethylhexadecanedioic acid (MEDICA 16) and compared with nontreated lean and obese animals. The

Mitochondrial protonophoric activity induced by a thyromimetic fatty acid analogue.

O Hermesh et al.

Biochimica et biophysica acta, 1457(3), 166-174 (2000-04-25)

Calcium-dependent uncoupling of liver mitochondrial oxidative phosphorylation by a non-metabolizable long chain fatty acyl analogue was compared with uncoupling induced by in vivo thyroid hormone treatment. beta,beta'-Methyl-substituted hexadecane alpha, omega-dioic acid (Medica 16) is reported here to induce a saturable

Inhibition of rat liver acetyl-CoA carboxylase by beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16).

G Rose-Kahn et al.

Biochimica et biophysica acta, 1042(2), 259-264 (1990-02-06)

Rat liver acetyl-CoA carboxylase activity was inhibited by the free as well as the CoA monothioester of beta, beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) (Bar-Tana, J., Rose-Kahn, G. and Srebnik, M. (1985) J. Biol. Chem. 260, 8404-8410 (1985). (1) The CoA

Suppression of hepatocyte nuclear factor-4alpha by acyl-CoA thioesters of hypolipidemic peroxisome proliferators.

R Hertz et al.

Biochemical pharmacology, 61(9), 1057-1062 (2001-04-13)

Hepatocyte nuclear factor-4alpha (HNF-4alpha) modulates the expression of liver-specific genes that control the production (e.g. apolipoprotein [apo] A-I and apo B) and clearance (e.g. apo C-III) of plasma lipoproteins. We reported that the CoA thioesters of amphipathic carboxylic hypolipidemic drugs

Effect of beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16) on laying hen performance and egg yolk lipid composition.

R G Elkin et al.

British poultry science, 33(3), 677-681 (1992-07-01)

1. beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16), an inhibitor of hepatic cholesterogenesis and lipogenesis in rats, was orally administered to 24-week-old White Leghorn hens for a period of 16 d. Hens were fed maize-soya-bean meal diets containing 0, 1.5, or

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