M4565
Matrix Metalloproteinase-7 human
~0.1 mg/mL, recombinant, expressed in E. coli, buffered aqueous solution
Sinónimos:
MMP-7, Matrilysin-1
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About This Item
Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.32
Productos recomendados
recombinante
expressed in E. coli
Nivel de calidad
formulario
buffered aqueous solution
actividad específica
5,000 units/mg protein
mol peso
20 kDa
concentración
~0.1 mg/mL
Nº de acceso UniProt
enfermedades relevantes
cancer
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
Información sobre el gen
human ... MMP7(4316)
Descripción general
Matrix metalloproteinase-7 (MMP7) also referred to as matrilysin is encoded by the gene mapped to human chromosome 11q21-q22. MMP7 is a smallest member of MMP enzyme family and is highly expressed in cancer cells. MMP7 is exclusively released by epithelial cells.
Aplicación
Matrix metalloproteinase-7 (MMP7) human has been used in in silico analysis of MMP-7 proteolysis of perlecan.
Acciones bioquímicas o fisiológicas
Matrix metalloproteinase-7 (MMP-7) catalyzes the cleavage of extracellular matrix (ECM) proteins such as proteoglycans, fibronectin, entactin, laminin, collagen III/ IV/ V/ IX/ X/ XI, type I/ II/ IV/ V gelatins, and elastin. Matrix metalloproteinase-7 facilitates initial stages of tumor progression. Activated MMP7 plays a vital role in human colorectal cancer (CRC) liver metastases. Overexpression of MMP7 is observed in various human cancers, such as breast, lung, prostate, esophagus, stomach, endometrium, and ovarian carcinomas, as well as esophageal squamous cell carcinomas. Increased expression of MMP7 is also associated with pathogenesis of demyelinating multiple sclerosis (MS) lesions. Both in silico and in vitro studies show that MMP7 degrades glycosylated and basement membrane bound perlecan and plays a vital role in prostate cancer cell invasion.
Forma física
Solution in 10 mM HEPES, 5 mM CaCl2, 150 mM NaCl
Nota de análisis
One unit of enzyme activity is defined as the digestion of 1 μg of azocoll/min. at pH 7.5 and 37 °C.
Código de clase de almacenamiento
10 - Combustible liquids
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior.
Grindel BJ, et.al.
Matrix Biology, 36, 64-76 (2014)
Enhanced expression of MMP-7 and MMP-9 in demyelinating multiple sclerosis lesions.
Cossins JA
Acta Neuropathologica, 94(6), 590-598 (1997)
Matrilysin.
Wilson, C.L. et al.
Matrix Metalloproteinases, 149-149 (1998)
Mapping of the metalloproteinase gene matrilysin (MMP7) to human chromosome 11q21-->q22.
Knox JD
Cytogenetics and Cell Genetics, 72(2-3), 179-182 (1996)
Matrix metalloproteinase-7 expression in colorectal cancer liver metastases: evidence for involvement of MMP-7 activation in human cancer metastases.
Zeng ZS
Clinical Cancer Research, 8(1), 144-148 (2002)
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