M1196

Anti-Mucolipin-2 (C-terminal) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-MCOLN2, Anti-MLN2, Anti-TRPML2
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 200
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: antigen ~60 kDa
• reactividad de especies: human
• envase: antibody small pack of 25 μL
• validación mejorada: recombinant expression; Learn more about Antibody Enhanced Validation
• concentración: ~1 mg/mL
• técnicas: western blot: 0.3-0.6 μg/mL using HEK-293T cells expressing human mucolipin-2
• Nº de acceso UniProt: Q8IZK6
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... MCOLN2(255231)

Descripción

Descripción general

Mucolipin-2 (MLN2) is a member of transient receptor potential (TRP) protein superfamily. It consists of gated, tetrameric cation channels. MLN2 has a conserved structure of six transmembrane helices with differing cytoplasmic oriented N- and C-terminal domains. It is localized to late endosomes and lysosomes..

Especificidad

Additional bands may be observed at ~120 kDa and ~35 kDa due to aggregation and degradation, respectively.

Inmunógeno

synthetic peptide corresponding to amino acids 534-549 of human mucolipin-2. This sequence has low homology with rat (73% identity) and mouse (66% homology) mucolipin-2.

Aplicación

Anti-Mucolipin-2 (C-terminal) antibody produced in rabbit has been used in immunoblotting.

Acciones bioquímicas o fisiológicas

Mucolipin-2 (MLN2) plays an important role in lysosome maturation, lysosome fission, late endosome-lysosome fusion, autophagosome-lysosome fusion, lysosome expulsion and iron release. It stimulates autophagy proliferation via transcription factor EB (TFEB) activation. MLN2 is involved in B‐lymphocyte development.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)