M0939

Anti-α-MSH antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Sinónimos: Anti-α-Melanocyte Stimulating Hormone
• Número MDL: MFCD03454727
• Código UNSPSC: 12352203
• NACRES: NA.46

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: IgG fraction of antiserum
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: antigen 1664.9 kDa
• reactividad de especies: human
• técnicas: ELISA: 1:4,000; microarray: suitable
• Nº de acceso UniProt: P01189
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... POMC(5443)

Descripción

Descripción general

Pro-opiomelanocortin (POMC), a complex pro-peptide is expressed in hypothalamus, pituitary gland, skin and the immune system. This gene is located on human chromosome 2p23.3.

Inmunógeno

synthetic α-MSH peptide conjugated to bovine serum albumin.

Aplicación

Anti-α-MSH antibody produced in rabbit has been used in:

• immunohistochemistry
• radioimmunoassay/α-MSH immunoassay
• enzyme linked immunosorbent assay (ELISA)

Acciones bioquímicas o fisiológicas

α-MSH (melanocyte stimulating hormone) and melanocortin-4-receptor (MC4R) are key signaling components in the control of energy homeostasis and of the hypothalamic response to obesity. Mutations that reduce the functional activity of -MSH lead to obesity in mammals and mice lacking the MC4 receptor (MC4R-/-) are hyperphagic and very obese, indicating that -MSH signaling transduced by MC4-R limits food intake and body fat mass.

α-Melanocyte Stimulating Hormone (α-MSH) stimulates the production of melanin in melanocytes and induced pigmentation and skin darkening. It increases the activity of tyrosinase that induces melanogenesis. α-MSH has potent anti-inflammatory effects and is also a neuromodulator. Analogs of α-MSH may be used to study melanogenesis and neuromodulation.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable