L0419
Anti-LAMP1−Cy3™ antibody produced in rabbit
1-2 mg/mL, affinity isolated antibody, buffered aqueous solution
Sinónimos:
Anti-CD107a, Anti-LAMPA, Anti-LGP120, Anti-Lysosomal-associated membrane protein 1
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About This Item
Productos recomendados
origen biológico
rabbit
Nivel de calidad
conjugado
CY3 conjugate
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
reactividad de especies
mouse, human, rat
concentración
1-2 mg/mL
técnicas
direct immunofluorescence: 1-2 μg/mL using human HeLa cells, rat NRK cells and mouse 3T3 cells
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
2-8°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... LAMP1(3916)
mouse ... Lamp1(16783)
rat ... Lamp1(25328)
Descripción general
Lysosomal-associated membrane protein 1 (LAMP1), also termed LGP120, is a heavily glycosylated lysosomal membrane protein with a molecular mass of 120 kDa. It consists of a 40 kDa core polypeptide with O-linked and 18 asparagine-linked oligosaccharide side chains. LAMP1 protein contains a leader sequence, a large intralumenal region consisting of 2 homologous domains separated by a hinge region rich in proline and serine, a 24-amino acid transmembrane region, and a short cytoplasmic tail containing the lysosomal membrane targeting signal.
The gene LAMP1 (lysosomal-associated membrane protein 1) encodes a type I transmembrane protein that has a short cytoplasmic tail containing a lysosome-targeting signal of GYQTI(382)-COOH. The gene is mapped to human chromosome 13q34.
Aplicación
Anti-LAMP1-Cy3™ antibody produced in rabbit has been used in immunofluorescence.
Acciones bioquímicas o fisiológicas
The gene LAMP1 (lysosomal associated membrane protein 1) encodes a membrane glycoprotein that functions as an intracellular receptor. It is found to be expressed in the cytoplasm of several types of tumor cells and may be involved in tumor invasion. Lamp1 is crucial for perforin trafficking to the lytic granules and motility of these lytic granules. Its knockdown leads to inhibition of cytotoxicity of human natural killer cells.
Forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Información legal
Cy3 is a trademark of Cytiva
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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The research into the pathophysiology of atherosclerosis has considerably increased our understanding of the disease complexity, but still many questions remain unanswered, both mechanistically and pharmacologically. Here, we provided evidence that the pro-oxidant enzyme Prenylcysteine Oxidase 1 (PCYOX1), in the
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