K3269

Anti-Kindlin-2 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-FERMT2, Anti-Fermitin family homolog 2, Anti-KIND2, Anti-MIG2, Anti-Mitogen inducible gene 2 protein, Anti-PLEKHC1, Anti-Pleckstrin homology domain containing, family C member 1, Anti-UNC112, Anti-UNC112B
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: antigen ~72 kDa
• reactividad de especies: mouse, rat, canine, human
• concentración: ~1.0 mg/mL
• técnicas: indirect immunofluorescence: 2-5 μg/mL using canine MDCK cells; western blot: 1-2 μg/mL using whole extracts of human HeLa, mouse P19 or rat AT3B-1 cells
• Nº de acceso UniProt: Q96AC1
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... FERMT2(10979) ; mouse ... Fermt2(218952) ; rat ... Fermt2(289992)

Descripción

Descripción general

Anti-kindlin-2 recognizes human, mouse, rat and canine kindlin-2. Kindlin-2, also known as fermitin family member 2 (FERMT2) or pleckstrin homology domain-containing family C member 1 (PLEKHC1), is encoded by the gene mapped to human chromosome 14q22.1. Kindlin-2 is a member of the kindlin protein family and has a ubiquitous expression pattern.

Aplicación

Anti-kindlin-2 antibody produced in rabbit has been used in western blotting.

Acciones bioquímicas o fisiológicas

Kindlin-2 acts as a focal adhesion protein and controls breast cancer progression by promoting genome instability. Kindlin-2, as an integrin-interacting protein, plays a vital role in integrin activation and integrin-mediated cell-extracellular matrix (ECM) interaction. Kindlin-2 expression is associated with poor prognosis of patients with hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinomas (PDACs). Therefore, kindlin-2 can be considered as a potential biomarker for patients with HCC and PDACs.

Forma física

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Almacenamiento y estabilidad

For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Otras notas

In order to obtain best results in different techniques and preparations we recommend determining optimal working concentration by titration test.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable