K0629

Sodium 4-methyl-2-oxovalerate

leucine metabolite

• Sinónimos: α-Ketoisocaproic acid sodium salt, 4-Methyl-2-oxopentanoic acid sodium salt, 4-Methyl-2-oxovaleric acid sodium salt, Ketoleucine sodium salt
• Fórmula lineal: (CH₃)₂CHCH₂COCOONa
• Número de CAS: 4502-00-5
• Peso molecular: 152.12
• Beilstein: 4239297
• Número CE: 224-816-3
• Número MDL: MFCD00064193
• Código UNSPSC: 12352107
• ID de la sustancia en PubChem: 24896196
• NACRES: NA.25

Propiedades

• Nivel de calidad: 100
• Ensayo: >98% (TLC)
• Formulario: powder
• técnicas: HPLC: suitable
• color: white to off-white
• mp: 275 °C (dec.) (lit.)
• aplicaciones: cell analysis
• temp. de almacenamiento: 2-8°C
• cadena SMILES: [Na+].CC(C)CC(=O)C([O-])=O
• InChI: 1S/C6H10O3.Na/c1-4(2)3-5(7)6(8)9;/h4H,3H2,1-2H3,(H,8,9);/q;+1/p-1
• Clave InChI: IXFAZKRLPPMQEO-UHFFFAOYSA-M

Descripción

Aplicación

Sodium 4-methyl-2-oxovalerate has been used for quantifying branched-chain keto acids from cell extracts by HPLC-fluorescence method.

Acciones bioquímicas o fisiológicas

α-Ketoisocaproic acid is a leucine metabolite that is known to induce insulin secretion from the βcells of pancreas. Enteral infusion of aα-Ketoisocaproate is found to ameliorate, endotoxemic condition. The resulting ketone bodies obtained from its conversion, might serve as an energy source. Accumulation of α-Ketoisocaproic acid is characterized in branched chain ketoaciduria, which is caused due to the lack of branched chain L-2-keto acid dehydrogenase activity. α-Ketoisocaproic acid causes dissociation in the oxidative phosphorylation reaction and acts as a metabolic inhibitor of α-ketoglutarate dehydrogenase. Thus, leads to a defect in the mitochondrial homeostasis, observed in branched chain ketoaciduria.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H319
• Consejos de prudencia: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Clasificaciones de peligro: Eye Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)