I8909
Anti-Interleukin-1α antibody produced in goat
IgG fraction of antiserum, lyophilized powder
Sinónimos:
Anti-IL-1α
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About This Item
Productos recomendados
origen biológico
goat
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
IgG fraction of antiserum
tipo de anticuerpo
primary antibodies
clon
polyclonal
formulario
lyophilized powder
reactividad de especies
human
técnicas
neutralization: suitable
western blot: 1-2 μg/mL
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
human ... IL1A(3552)
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Descripción general
Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced by the activation of NF-κ B transcription factor in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signalling through IL-1 receptor type 1. A variety of cells such as macrophages, epithelial cells, fibroblasts, keratinocytes, monocytes and dendritic cells secrete IL-1α. Both IL-1α and IL-1β are important in acquired immunity, inflammation, response to infection and production of matrix metalloproteinases (MMPs). The effects of IL-1α are mediated by activation of NF-κB, JNK and MAPK pathways that activated the genes in response to infection and inflammation. Overproduction of IL-1α has been implicated in inflammatory disorders like rheumatoid arthritis and periodontitis
Anti-interleukin-1α specifically reacts with human IL-1α. It does not react with human IL-1β and mouse IL-1β or mouse IL-1α in neutralization reactions. It shows 5% cross reactivity with mouse IL-1α in immunoblotting applications.
Anti-interleukin-1α specifically reacts with human IL-1α. It does not react with human IL-1β and mouse IL-1β or mouse IL-1α in neutralization reactions. It shows 5% cross reactivity with mouse IL-1α in immunoblotting applications.
Inmunógeno
purified, E. coli-derived recombinant human interleukin-1α.
Aplicación
Anti-interleukin 1α antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. It is also suitable for neutralization reactions.
Forma física
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
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Código de clase de almacenamiento
10 - Combustible liquids
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Interleukin-1 (IL-1) pathway
Weber A et al
Science Signaling, 3, p-p (2010)
S Z Ben-Sasson et al.
Cytokine, 56(1), 122-125 (2011-08-17)
IL-1 strikingly enhances antigen-driven responses of CD4 and CD8 T cells. It is substantially more effective than LPS and when added to a priming regime of antigen plus LPS, it strikingly enhances cell expansion. The effect is mediated by direct
Charles A Dinarello
Current opinion in pharmacology, 4(4), 378-385 (2004-07-15)
All biological agents currently used for reducing TNFalpha activity in disease are neutralization strategies; however, there are several strategies for reducing interleukin (IL)-1 activities: the IL-1 receptor antagonist (IL-1Ra), anti-IL-1beta monoclonal antibodies, the IL-1 Trap, IL-1 receptor type I antibodies
Emmanuel Contassot et al.
Swiss medical weekly, 142, w13590-w13590 (2012-06-02)
Interleukin 1, one of the first cytokines discovered in the 1980s, and a potent mediator of fever, pain and inflammation, is at present experiencing a revival in biology and medicine. Whereas the mechanism of activation and secretion of interleukin 1β
H E Barksby et al.
Clinical and experimental immunology, 149(2), 217-225 (2007-06-26)
Understanding cytokine immunobiology is central to the development of rational therapies for destructive inflammatory diseases such as rheumatoid arthritis (RA) and periodontitis. The classical interleukin-1 (IL-1) family cytokines, IL-1alpha and IL-1beta, as well as IL-18, play key roles in inflammation.
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