I4028

Monoclonal Anti-Interleukin-18 Receptor antibody produced in mouse

clone 70625.111, purified immunoglobulin, lyophilized powder

• Sinónimos: Anti-IL-18 Receptor
• Número MDL: MFCD02096767
• Código UNSPSC: 51111800
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 200
• conjugado: unconjugated
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: 70625.111, monoclonal
• formulario: lyophilized powder
• reactividad de especies: human
• técnicas: flow cytometry: suitable (2.5μg/SUP>10^{6 cell)}; immunocytochemistry: 8-25 μg/mL; immunohistochemistry: 8-25 μg/mL
• isotipo: IgG1
• Nº de acceso UniProt: Q13478
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... IL18R1(8809)

Descripción

Descripción general

The antibody will neutralize the biological activity of recombinant human IL-18 receptor.

Inmunógeno

recombinant human IL-18 receptor extracellular domain, expressed in NS0 cells.

Acciones bioquímicas o fisiológicas

IL-18 belongs to the IL-1 cytokine superfamily and is a regulator of innate and acquired immune responses. The immune responses of IL-18 are mediated by its interaction and subsequent signaling by IL-18 receptor complex. The IL-18R complex is made up of α chain that binds to extracellular IL-18 and a β chain that is involved in signal transduction. The IL-18/IL-18R signaling enhances T and NK cell maturation, cytotoxicity and secretion of cytokines.

Forma física

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Nota de preparación

Purified using protein G.

Información de seguridad

• Código de clase de almacenamiento: 13 - Non Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable