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I3657

Sigma-Aldrich

Insulin-Like Growth Factor Binding Protein-2 from mouse

≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

Sinónimos:

IGFBP-2

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About This Item

Número MDL:
MFCD02099094
Código UNSPSC:
51111800
NACRES:
NA.32

origen biológico

mouse

Nivel de calidad

200

recombinante

expressed in NSO cells

Análisis

≥95% (SDS-PAGE)

formulario

lyophilized powder

potencia

0.125-0.5 mg per mL ED50

mol peso

~35 kDa by SDS-PAGE (reducing)
calculated mol wt 29.4 kDa

envase

pkg of 25 μg

técnicas

cell culture | mammalian: suitable

impurezas

endotoxin, tested

Nº de acceso UniProt

D3YU40

temp. de almacenamiento

−20°C

Información sobre el gen

mouse ... Igfbp2(16008)

Descripción general

IGFBP2 (insulin-like growth factor binding protein 2) belongs to the IGFBP family of proteins. The protein has two HBD (heparin-binding domain-1) domains. It is a secreted protein.

Acciones bioquímicas o fisiológicas

During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology.
IGFBP2 (insulin-like growth factor binding protein 2) works along with IGF-I (insulin like growth factor I) and regulates cellular proliferation and differentiation. It mainly binds to IGFs and restricts their association to other receptors.

Forma física

Lyophilized from a 0.2 μm filtered solution of 35% acetonitrile and 0.1% TFA.

Nota de análisis

The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Gang Xi et al.
Endocrinology, 154(11), 4146-4157 (2013-08-29)
IGF-binding protein (IGFBP)-2 overexpression confers resistance to high-fat feeding and inhibits the differentiation of preadipocytes in vitro. However, whether administration of IGFBP-2 can regulate adipogenesis in vivo and the domains that mediate this response have not been defined. IGFBP-2 contains
Hye Suk Kang et al.
The Biochemical journal, 467(3), 453-460 (2015-02-20)
Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorders is well known, its regulatory mechanism remains unclear. In
Gang Xi et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 29(11), 2427-2438 (2014-05-20)
Insulin-like growth factor binding protein 2 (IGFBP-2) is important for acquisition of normal bone mass in mice; however, the mechanism by which IGFBP-2 functions is not defined. These studies investigated the role of IGFBP-2 in stimulating osteoblast differentiation. MC-3T3 preosteoblasts
Xinchun Shen et al.
The Journal of biological chemistry, 290(18), 11578-11590 (2015-03-20)
Insulin-like growth factor-binding protein-2 (IGFBP-2) functions coordinately with IGF-I to stimulate cellular proliferation and differentiation. IGFBP-2 binds to receptor tyrosine phosphatase β (RPTPβ), and this binding in conjunction with IGF-I receptor stimulation induces RPTPβ polymerization leading to phosphatase and tensin

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