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Merck
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Key Documents

HPA031613

Sigma-Aldrich

Anti-CCR4 antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Sinónimos:

Anti-CC-CKR-4, Anti-CD194, Anti-CKR4, Anti-CMKBR4, Anti-ChemR13, Anti-chemokine (C-C motif) receptor 4, Anti-k5-5

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About This Item

Código UNSPSC:
12352203
Atlas de proteínas humanas número:
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Línea del producto

Prestige Antibodies® Powered by Atlas Antibodies

formulario

buffered aqueous glycerol solution

reactividad de especies

human

validación mejorada

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

técnicas

immunohistochemistry: 1:20- 1:50

secuencia del inmunógeno

LQIYSADTPSSSYTQSTMDHDLHDAL

Nº de acceso UniProt

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... CCR4(1233)

Descripción general

CCR4 (carbon catabolite repressor protein 4 homolog), a C-C type chemokine receptor. CCR4 is precisely expressed on surfaces of cells such as T helper type 2 cells, regulatory T cells, interluekin-17–producing T-helper cells (Th17), and skin-homing memory. These cells are usually known to migrate toward the chemokines CCL17 (C-C motif chemokine 17) and CCL22 (C-C motif chemokine 20).

Inmunógeno

chemokine (C-C motif) receptor 4 recombinant protein epitope signature tag (PrEST)

Aplicación

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

Acciones bioquímicas o fisiológicas

CCR4 (carbon catabolite repressor protein 4 homolog) plays an important role in immune cell trafficking. CCR4 is associated with the immunopathogenesis of hematological tumors and serves as an important biomarker in various types of cancer. CCR4 is involved in tumor growth and metastasis of many malignancies including gastric cancer. CCR4 is involved in tumor-induced immunosuppression. Mutations in CCR4 is associated with adult T cell leukaemia/lymphoma.

Características y beneficios

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Ligadura / enlace

Corresponding Antigen APREST78150

Forma física

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Información legal

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

CCR4 frameshift mutation identifies a distinct group of adult T cell leukaemia/lymphoma with poor prognosis.
Yoshida N
The Journal of Pathology, 238(5), 621-626 (2016)
Distinct conformations of the chemokine receptor CCR4 with implications for its targeting in allergy.
Viney JM
Journal of Immunology, 192(7), 3419-3427 (2014)
A balanced chromosomal translocation involving chromosomes 3 and 16 in a patient with Mayer-Rokitansky-Kuster-Hauser syndrome reveals new candidate genes at 3p22.3 and 16p13.3.
Williams LS
Molecular Cytogenetics, 9:57, 1-7 (2016)
Takashi Kurashige et al.
Journal of neuropathology and experimental neurology, 79(4), 448-457 (2020-02-27)
Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and antisignal recognition particle (SRP) antibodies are frequently associated with immune-mediated necrotizing myopathy (IMNM). However, the difference in clinical manifestations between anti-HMGCR and anti-SRP antibodies is unclear. HMGCR is an essential enzyme for cholesterol biosynthesis and
Expression of chemokine receptor 4 was associated with poor survival in renal cell carcinoma.
Liu Q
Medical Oncology (Northwood, London, England), 31(4), 882-882 (2014)

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