HPA028850

Anti-TFAP2A antibody produced in rabbit

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

• Sinónimos: Anti-AP-2, Anti-AP2TF, Anti-BLTR, Anti-CMKRL1, Anti-GPR16, Anti-LTB4R1, Anti-P2RY7, Anti-P2Y7, Anti-TFAP2, Anti-transcription factor AP-2 α (activating enhancer binding protein 2 α)
• Código UNSPSC: 12352203
• Atlas de proteínas humanas número: HPA028850
• NACRES: NA.43

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Línea del producto: Prestige Antibodies^® Powered by Atlas Antibodies
• Formulario: buffered aqueous glycerol solution
• reactividad de especies: rat, human
• validación mejorada: orthogonal RNAseq; independent; Learn more about Antibody Enhanced Validation
• técnicas: immunoblotting: 0.04-0.4 μg/mL; immunofluorescence: 0.25-2 μg/mL; immunohistochemistry: 1:1000-1:2500
• secuencia del inmunógeno: RHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKD
• Nº de acceso UniProt: P05549
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... TFAP2A(7020)

Descripción

Descripción general

The gene TFAP2A (transcription factor AP-2-α) is mapped to human chromosome 6p24.3. It is a transcription factor. The protein has a helix-span-helix motif for DNA binding. TFAP2A protein can bind to G/C-rich elements. It belongs to the AP-2 transcription factor family of proteins.

Inmunógeno

transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) recombinant protein epitope signature tag (PrEST)

Aplicación

All Prestige Antibodies^®Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.
Anti-TFAP2A antibody produced in rabbit has been used as a capturing agent for immunoenrichment coupled mass spectrometry.

Acciones bioquímicas o fisiológicas

TFAP2A (transcription factor AP-2-α) is involved in development, apoptosis and cell cycling, and oncogenesis. It is upregulated in presence of Hepatitis B virus X and is responsible for hepatoma cell growth. Changes in the expression of this gene are linked with various cancers, such as melanoma, prostate, breast, ovarian, gastric, colon and bladder cancers. TFAP2A controls expression of genes associated with proliferation (c-MYC), cell cycle (HER-2 (receptor tyrosine-protein kinase) and p21WAF1 (cyclin-dependent kinase inhibitor 1)), cell death (c-KIT (tyrosine-protein kinase), Bcl-2 (B-cell lymphoma 2), and FAS (tumor necrosis factor receptor superfamily member)), cell attachment (MUC18 (melanoma-associated antigen) and E-cadherin), and tumor invasion/angiogenesis (MMP-9 (matrix metalloproteinase), PAI-I (plasminogen activator inhibitor), and PAR-1 (protease-activated receptor)). Mutations in this gene are associated with branchio-oculo-facial syndrome.

Características y beneficios

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Ligadura / enlace

Corresponding Antigen APREST77632

Forma física

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Información legal

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable