HPA026763

Anti-NENF antibody produced in rabbit

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

• Sinónimos: Anti-Cell immortalization-related protein 2, Anti-Neudesin, Anti-Neuron-derived neurotrophic factor, Anti-SPUF protein, Anti-Secreted protein of unknown function
• Código UNSPSC: 12352203
• Atlas de proteínas humanas número: HPA026763
• NACRES: NA.41
• conjugado: unconjugated
• application: IF; IHC
• clon: polyclonal
• reactividad de especies: human
• citations: 3
• técnicas: immunofluorescence: 0.25-2 μg/mL; immunohistochemistry: 1:20-1:50

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Línea del producto: Prestige Antibodies^® Powered by Atlas Antibodies
• Formulario: buffered aqueous glycerol solution
• reactividad de especies: human
• técnicas: immunofluorescence: 0.25-2 μg/mL; immunohistochemistry: 1:20-1:50
• secuencia del inmunógeno: RLFTEEELARYGGEEEDQPIYLAVKGVVFDVTSGKEFYGRGAPYNALTGKDSTRGVAKMS
• Nº de acceso UniProt: Q9UMX5
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... NENF(29937)

Descripción

Descripción general

Neuron derived neurotrophic factor (NENF), also called as neudesin and GIG47, is mapped to human chromosome 1p33. This gene is expressed only in vertebrates. NENF codes for a novel secretory protein with 172 amino acids named neudesin. Primary structure of this protein might contain cytochrome b5-like heme/steroid-binding domain. In mouse, neudesin is expressed in heart, kidney, brain, and lung.

Inmunógeno

Neudesin Precursor recombinant protein epitope signature tag (PrEST)

Aplicación

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Acciones bioquímicas o fisiológicas

Neuron derived neurotrophic factor (NENF) or GIG47 as an oncogene plays a crucial role in human tumorigenesis. It is highly expressed in various human cancer tissues, such as uterine cervix cancer, lymphoma, colon, lung, skin, leukemia and even breast cancer. Neudesin acts as a neurotrophic factor in neurons and undifferentiated neural cells. The neurotrophic property of this protein is transmitted by the activation of mitogen-activated protein (MAP) and phosphatidylinositol 3-kinase (PI-3K) pathways. NENF or neudesin is a primary extracellular heme-binding protein implicated in intercellular signal transduction. In mouse, neudesin plays a vital role in neural cell proliferation and neuronal differentiation.

Características y beneficios

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Ligadura / enlace

Corresponding Antigen APREST76694

Forma física

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Información legal

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable