HPA023887

Anti-FYN antibody produced in rabbit

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

• Sinónimos: Anti-Proto-oncogene tyrosine-protein kinase Fyn, Anti-Protooncogene Syn, Anti-SLK, Anti-p59-Fyn
• Número MDL: MFCD01633360
• Código UNSPSC: 12352203
• Atlas de proteínas humanas número: HPA023887
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Línea del producto: Prestige Antibodies^® Powered by Atlas Antibodies
• Formulario: buffered aqueous glycerol solution
• reactividad de especies: mouse, human, rat
• validación mejorada: RNAi knockdown; Learn more about Antibody Enhanced Validation
• técnicas: immunoblotting: 0.04-0.4 μg/mL; immunofluorescence: 0.25-2 μg/mL; immunohistochemistry: 1:50-1:200
• secuencia del inmunógeno: SFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIR
• Nº de acceso UniProt: P06241
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... FYN(2534)

Descripción

Descripción general

FYN (proto-oncogene, Src family tyrosine kinase) is located in human chromosome 6q21.

Fyn is a non-receptor type tyrosine kinase also called as tau kinase, which belongs to the Src family. It has two isoforms, FynB and FynT, expressed in brain and T-lymphocytes, respectively. The Fyn protein consist of Src homology domain 2 (SH2) and Src homology domain 3 (SH3) at its amino terminal ends.

Inmunógeno

FYN proto-oncogene, Src family tyrosine kinase

Aplicación

Anti-FYN antibody has been used in western blotting and sodium dodecyl sulphate-polyacrylamide gel electrophoresis.

Anti-FYN antibody produced in rabbit has been used for Western blotting. All Prestige Antibodies^®Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Acciones bioquímicas o fisiológicas

FynT, an isoform of tyrosine-protein kinase Fyn, regulates neurofibrillary degeneration and reactive astrogliosis in Alzheimer′s disease (AD). The tyrosine kinase Fyn plays a vital role in acute transplant rejection, by phosphorylating tyrosine residues on key targets that take part in early T-cell signal transduction, which is a crucial process for acute transplant rejection. p59fyn (T) controls OKT3 promoted calcium ion transport in Jurkat T cells . Fyn facilitates the phosphorylation of Vav, a guanine nucleotide exchange factor for Rho-like small GTPases, and plays a crucial role in TCR-mediated actin polymerization. The Fyn protein associates with large myelin-associated glycoprotein (MAG) and plays a major role in myelinogenesis.

Características y beneficios

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Ligadura / enlace

Corresponding Antigen APREST78892

Forma física

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Información legal

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable