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Merck
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Documentos clave

HPA001474

Sigma-Aldrich

Anti-OASL antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

Sinónimos:

Anti-59 kDa 2′→5′-Oligoadenylate synthetase-like protein antibody produced in rabbit, Anti-TRIP-14 antibody produced in rabbit, Anti-Thyroid receptor-interacting protein 14 antibody produced in rabbit, Anti-p59 OASL antibody produced in rabbit, Anti-p59OASL antibody produced in rabbit

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About This Item

Código UNSPSC:
12352203
Atlas de proteínas humanas número:
HPA001474
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

100

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

buffered aqueous glycerol solution

reactividad de especies

human

técnicas

immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL

secuencia del inmunógeno

EVLDAVRTVEEFLRQEHFQGKRGLDQDVRVLKVVKVGSFGNGTVLRSTREVELVAFLSCFHSFQEAAKHHKDVLRLIWKTMWQSQDLLDLGLEDLRMEQRVPDALVFTIQTRGTAEPITVTIVPAYRAL

Nº de acceso UniProt

Q15646

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... OASL(8638)

Categorías relacionadas

Inmunógeno

59 kDa 2′→5′-Oligoadenylate synthetase-like protein recombinant protein epitope signature tag (PrEST)

Aplicación

Anti-OASL antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

Acciones bioquímicas o fisiológicas

OASL (2′-5′-oligoadenylate synthetase-like) is a 59kDa protein that is an atypical member of the OAS family as it does not possess the characteristic 2′-5′ oligoadenylate synthetase activity. It exhibits an antiviral effect against the single-stranded RNA viruses, such as, picornavirus, encephalomyocarditis virus. It inhibits hepatitis C viral replication in vitro. OASL interacts with the transcriptional repressor Methyl CpG-binding protein 1 (MBD1) upon interferon stimulation.

Características y beneficios

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Ligadura / enlace

Corresponding Antigen APREST83083

Forma física

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Información legal

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificados de análisis (COA)

Lot/Batch Number
R00644
R000644

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Joao Marques et al.
The Journal of general virology, 89(Pt 11), 2767-2772 (2008-10-22)
Viral infection of mammalian cells prompts the innate immune system to initiate an antiviral response. The recognition of the virus triggers several antiviral signalling pathways, which among others include the family of 2'-5' oligoadenylate synthetase (OAS) proteins. The p59 protein
Jesper B Andersen et al.
European journal of biochemistry, 271(3), 628-636 (2004-01-20)
The human 2'-5' oligoadenylate synthetases (OAS) form a conserved family of interferon-induced proteins consisting of four genes: OAS1, OAS2, OAS3 and the 2'-5' oligoadenylate synthetase-like gene (OASL). When activated by double-stranded RNA, OAS1-3 polymerize ATP into 2'-5'-linked oligoadenylates; 2'-5'-linked oligoadenylates
Mariko Ishibashi et al.
Biochemical and biophysical research communications, 392(3), 397-402 (2010-01-16)
We found the 2',5'-oligoadenylate synthetase-like (OASL) gene to be significantly elevated by high virus loads in human liver infected with hepatitis C virus (HCV). Here, we determined whether OASL inhibited HCV replication using an in vitro system. We constructed three
Shoichiro Tanaka et al.
Diabetes, 58(10), 2285-2291 (2009-07-31)
Fulminant type 1 diabetes is characterized by the rapid onset of severe hyperglycemia and ketoacidosis, with subsequent poor prognosis of diabetes complications. Causative mechanisms for accelerated beta-cell failure are unclear. Subjects comprised three autopsied patients who died from diabetic ketoacidosis

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