H9250
Histone from calf thymus
Type II-A, lyophilized powder
Sinónimos:
histone type VIII-S
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About This Item
Productos recomendados
origen biológico
bovine (calf) thymus
Nivel de calidad
tpo
Type II-A
Formulario
lyophilized powder
aplicaciones
cell analysis
temp. de almacenamiento
2-8°C
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Descripción general
Histones are octameric proteins containing H3, H4, H2A and H2B. It is the core protein around which DNA is wound forming the nucleosome structure. The core histone proteins contain globular domains. Each protein is composed of basic amino acids at its N-terminal. The H2A has an extra amino acid at its C-terminal end forming a histone tail. The nucleosome structure is stabilized by the linker histones during chromatin condensation.
Aplicación
Histone from calf thymus has been used:
- in methyltransferase reaction mixture for methyltransferase assay
- in in vitro binding assay, to explore the potential binding of the MORF4 (mortality factor on chromosome 4) - related gene on chromosome 15 (MRG15) chromo domain with histone
- in in vitro coculture assays, to stimulate liver resident Kupffer cells
Acciones bioquímicas o fisiológicas
The core histones are involved in histone-histone interactions and maintains the organization of the nucleosomal DNA. The histone tail helps in forming higher-order nucleosomal structures. The overall structure and action of chromatin fiber is regulated by histone modifications.
Características y beneficios
Do not confuse Sigma "Type" designations with the "Fraction" designations used by Luck and co-workers.
Nota de preparación
Unfractionated whole histone
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Zhang P, et al.
Nucleic Acids Research, 34(22), 6621-6628 (2006)
Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury
Huang H, et al.
Journal of Immunology, 191(5), 2665-2679 (2013)
Juan-Carlos Cabrera et al.
Glycobiology, 20(6), 775-786 (2010-03-05)
Plant cell walls undergo remodeling during growth and development and are the first target of many invading pathogens. Acidic pectin (homogalacturonans) binds calcium and forms chain dimers called egg boxes and even multimers at higher calcium ion concentrations. Chitosan, the
Yannick Tauran et al.
Scientific reports, 9(1), 5816-5816 (2019-04-11)
By means of Silicon Nano Tweezers (SNTs) the effects on the mechanical properties of λ-phage DNA during interaction with calf thymus nucleosome to form an artificial chromatin analog were measured. At a concentration of 100 nM, a nucleosome solution induced a
Adam F Kebede et al.
Nature structural & molecular biology, 24(12), 1048-1056 (2017-10-24)
Histones are highly covalently modified, but the functions of many of these modifications remain unknown. In particular, it is unclear how histone marks are coupled to cellular metabolism and how this coupling affects chromatin architecture. We identified histone H3 Lys14
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