H8666
Transforming Growth Factor-β2 human
TGF-β2, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
Sinónimos:
TGF-β2
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
About This Item
Productos recomendados
origen biológico
human
Nivel de calidad
recombinante
expressed in HEK 293 cells
Análisis
≥95% (SDS-PAGE)
formulario
lyophilized powder
potencia
≤0.5 ng/mL EC50
calidad
endotoxin tested
mol peso
dimer 25 kDa (non-glycosylated)
envase
pkg of 5 μg
condiciones de almacenamiento
avoid repeated freeze/thaw cycles
técnicas
cell culture | mammalian: suitable
impurezas
≤1 EU/μg
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
human ... TGFB2(7042)
¿Está buscando productos similares? Visita Guía de comparación de productos
Categorías relacionadas
Descripción general
Transforming growth factor-β2 (TGF-β2) belongs to the TGF-β superfamily. All threes isoforms (TGF-β1, TGF-β2 and TGF-β3) are known to share similar structure and function. The TGFB2 gene is mapped to human chromosome 1q41 and is localized to extracellular matrix. The active form of TGF-β precursor is produced upon proteolytic cleavage. TGF-β1 and TGF-β2 have 70% amino acid sequence identity.
Acciones bioquímicas o fisiológicas
TGF-β2 is important for immune homeostasis by balancing lymphocyte proliferation, apoptosis, hematopoiesis, and embryogenesis. TGF-β2 is crucial in cell growth, differentiation, and survival. TGF-β2 is a strong growth inhibitor for normal and transformed epithelial, lymphoid, fibroblast, and keratinocyte cells. TGF-β is associated with the process of tumor development, progression and metastasis. TGF-β2 is a tumor suppressor in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis. TGF-β2 inhibits antitumor action of NK (natural killer) cells, T-cells, macrophages, monocytes and neutrophils. TGF-β is also associated with inflammation and wound healing. The TGF-β gene is overexpressed in glioma tumors and also in colon cancer, gastric cancer and cervical lesions.
Transforming growth factor-β2 (TGF-β2), like TGF-β1, is produced by many cell types and reported to be most concentrated in mammalian platelets.
Nota de preparación
HumanKine TGF-β2 is expressed in human HEK 293 cells as a mature, non-glycosylated, disulfide-linked homodimer with a predicted molecular mass of approx. 25 kDa.
Nota de análisis
The specific activity was determined by the dose-dependent inhibition of IL-4 induced proliferation of mouse HT-2 (BALB/c spleen activated by sheep erythrocytes in the presence of IL-2).
Información legal
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Producto relacionado
Referencia del producto
Descripción
Precios
producto comparable
Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
TGF-β2?Induced Matrix Modification and Cell Transdifferentiation in the Human Lens Capsular Bag
Wormstone IM, et al.
Investigative Ophthalmology & Visual Science, 43, 2301-2308 (2002)
Curcumin suppresses doxorubicin-induced epithelial?mesenchymal transition via the inhibition of TGF-β and PI3K/AKT signaling pathways in triple-negative breast cancer cells.
Chen WC, et al.
Journal of Agricultural and Food Chemistry, 61.48, 11817-11824 (2013)
Sunder Sims-Lucas et al.
Differentiation; research in biological diversity, 79(4-5), 272-284 (2010-02-19)
Many members of the transforming growth factor-beta (TGF-beta) superfamily have been shown to be important regulators of metanephric development. In this study, we characterized the effect of TGF-beta2 on metanephric development. Rat and mouse metanephroi cultured in the presence of
Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm
Lindsay ME, et al.
Nature Genetics, 44(8), 922?927-922?927 (2012)
Transforming growth factor beta (TGF-β) and inflammation in cancer.
Bierie B, et al.
Cytokine & Growth Factor Reviews, 21(1):, 49-59 (2010)
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico