H6649

Herbimycin A from Streptomyces hygroscopicus

≥95% (HPLC), powder

• Fórmula empírica (notación de Hill): C₃₀H₄₂N₂O₉
• Número de CAS: 70563-58-5
• Peso molecular: 574.66
• Beilstein: 4834067
• Número MDL: MFCD00151702
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24895756
• NACRES: NA.77

Propiedades

• origen biológico: Streptomyces hygroscopicus
• Nivel de calidad: 200
• Ensayo: ≥95% (HPLC)
• Formulario: powder
• color: yellow
• solubilidad: DMSO: 7.5 mg/mL
• espectro de actividad antibiótica: viruses
• Modo de acción: enzyme | inhibits
• temp. de almacenamiento: −20°C
• cadena SMILES: CO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1OC)C2=O
• InChI: 1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1
• Clave InChI: MCAHMSDENAOJFZ-BVXDHVRPSA-N

Descripción

Descripción general

DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.

Herbimycin A from Streptomyces hygroscopicus is a benzoquinoid ansamycin antibiotic. It is an analog of geldanamycin.

Aplicación

Herbimycin A from Streptomyces hygroscopicus has been used as an inhibitor of Src tyrosine kinase in HEK293T cells and rat intestinal epithelial cells. It has also been used to test its attenuation effect in intimal hyperplasia (IH) post balloon injury in rat carotid artery.

Acciones bioquímicas o fisiológicas

An antibiotic that inhibits protein tyrosine kinase. Herbimycin A is a potent inhibitor of angiogenesis.

Herbimycin A is an inducer of heat shock protein (HSP). It increases HSP expression resulting in the attenuation of ischemia reperfusion induced pulmonary injury.

Precaución

Hygroscopic and photosensitive

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)