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Merck

H3291

Sigma-Aldrich

Anti-HOXD4 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-HHO.C13, Anti-HOX-4B, Anti-HOX-5.1

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen ~35 kDa

reactividad de especies

mouse, human

concentración

~1.0 mg/mL

técnicas

immunoprecipitation (IP): 1.5-3 μg using lysates of HEK-293T cells over-expressing human HOXD4
indirect immunofluorescence: 0.25-0.5 μg/mL using paraformaldehyde-fixed HEK-293T cells over-expressing human HOXD4
western blot: 0.5-1 μg/mL using mouse brain extract

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... HOXD4(3233)

Descripción general

The Homeobox D4 (HOXD4) gene is localized in mesodermal tissues and the central nervous system (CNS). The HOXD4 gene is located on the human chromosome at 2q31.1.

Especificidad

Anti-HOXD4 (N-terminal) recognizes human and mouse- HOXD4 (also known as HOX-4B, HOX-5).

Aplicación

Anti-HOXD4 (N-terminal) antibody produced in rabbit may be used in:
  • immunoblotting
  • immunoprecipitation
  • immunofluorescence

Acciones bioquímicas o fisiológicas

The Homeobox D4 (HOXD4) gene participates in tumorigenesis of the central nervous system. This gene acts as a biomarker in the diagnosis of gliomas. HOXD4 is involved in the evolution of spine and dura mater. It also participates in the etiology and pathogenesis of spinal extradural arachnoid cyst (SEDAC).

Forma física

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Almacenamiento y estabilidad

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Hui Liu et al.
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association, 25(1), 46-54 (2018-12-28)
Homeobox D4 (HOXD4) belongs to the homeobox (HOX) family, which plays a crucial role in the early embryo development and cell differentiation. The role of HOXD4 in human gastric adenocarcinoma has not been elucidated. In the present study, we aimed
Xin-Wei Zhao et al.
Oncotarget, 8(70), 115657-115666 (2018-02-01)
HOX (homologous box) is known as the dominant gene of vertebrate growth and cell differentiation. Abnormal expression of HOX gene in various tumors has attracted the attention of scholars. As a component of HOX clusters, HOXD4 plays a controversial role
Yoji Ogura et al.
PloS one, 10(11), e0142126-e0142126 (2015-11-07)
Spinal extradural arachnoid cyst (SEDAC) is a cyst in the spinal canal that protrudes into the epidural space from a defect in the dura mater and leads to neurological disturbances. We previously showed that familial SEDAC is caused by FOXC2

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