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Merck

GW21229

Sigma-Aldrich

Anti-CLIF antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-Cycle-like factor CLIF

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

chicken

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

reactividad de especies

human

fabricante / nombre comercial

Genway 15-288-21229

técnicas

western blot: suitable

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... CLIF(56938)

Categorías relacionadas

Inmunógeno

Immunogen Sequence: GI # 9910368, sequence 8-100
Recombinant transcription factor BMAL2

Aplicación

Anti-CLIF antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Acciones bioquímicas o fisiológicas

The CLIF gene encodes a member of the basic helix-loop-helix PER-ARNT-SIM family of transcription factors and is located on chromosome12. It helps in controlling diverse physiological processes including circadian rhythm. CLIF is expressed in endothelial cells and neurons in the brain, including the suprachiasmatic nucleus and the center of the circadian clock. In endothelial cells, it forms a heterodimer with CLOCK and up-regulates the PAI-1 gene through E-box sites. CLIF helps in regulating the circadian oscillation of PAI-1 gene expression in endothelial cells. Its expression is increased in colorectal cancer and is related to tumor invasiveness and aggressiveness.

Forma física

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Gianluigi Mazzoccoli et al.
Journal of cancer research and clinical oncology, 138(3), 501-511 (2011-12-27)
Cathepsin and plasmin may favor cancer cell invasion degrading extracellular matrix. Plasmin formation from plasminogen is regulated by plasminogen activator inhibitor type-1 (PAI-1). ARNTL2 activates the promoters of the PAI-1 gene, officially called SERPINE1, driving the circadian variation in circulating
K Maemura et al.
The Journal of biological chemistry, 275(47), 36847-36851 (2000-10-06)
The onset of myocardial infarction occurs frequently in the early morning, and it may partly result from circadian variation of fibrinolytic activity. Plasminogen activator inhibitor-1 activity shows a circadian oscillation and may account for the morning onset of myocardial infarction.
John A Schoenhard et al.
American journal of physiology. Cell physiology, 283(1), C103-C114 (2002-06-11)
The BMAL2 gene encodes a member of the basic helix-loop-helix PER-ARNT-SIM family of transcription factors, which control diverse physiological processes including circadian rhythms. We identified four novel human BMAL2 transcripts that differ by alternative splicing within their NH2-terminal regions. Divergent
M Ikeda et al.
Biochemical and biophysical research communications, 275(2), 493-502 (2000-08-31)
We isolated a human cDNA encoding a novel member of the bHLH-PAS transcription factor superfamily, BMAL2, which is highly similar to, but distinct from, BMAL1. The composite cDNA covered a 1720-bp sequence consisting of a putative 1653-bp open reading frame

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