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Merck
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G9910

Sigma-Aldrich

Sodium glycodeoxycholate

BioXtra, ≥97% (HPLC)

Sinónimos:

3α,12α-Dihydroxy-5β-cholan-24-oic acid N-(carboxymethyl)amide, Glycodeoxycholic acid sodium salt, Glycodesoxycholic acid, N-(3α,12α-Dihydroxy-24-oxocholan-24-yl)glycine

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About This Item

Fórmula empírica (notación de Hill):
C26H42NNaO5
Número de CAS:
16409-34-0
Peso molecular:
471.61
Número CE:
240-455-4
Número MDL:
MFCD00036742
Código UNSPSC:
12161900
ID de la sustancia en PubChem:
24895386
NACRES:
NA.25

descripción

anionic

Línea del producto

BioXtra

Análisis

≥97% (HPLC)

mol peso

471.61 g/mol

impurezas

≤0.0025% Phosphorus (P)
≤0.1% Insoluble matter

CMC

2.1 mM

solubilidad

H2O: 0.1 M, clear to slightly hazy, colorless to almost colorless

trazas de anión

chloride (Cl-): ≤1%
sulfate (SO42-): ≤0.05%

trazas de catión

Al: ≤0.0005%
Ca: ≤0.011%
Cu: ≤0.0005%
Fe: ≤0.001%
K: ≤0.005%
NH4+: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.003%

cadena SMILES

[Na].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCC(=O)NCC(O)=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

InChI

1S/C26H43NO5.Na.H/c1-15(4-9-23(30)27-14-24(31)32)19-7-8-20-18-6-5-16-12-17(28)10-11-25(16,2)21(18)13-22(29)26(19,20)3;;/h15-22,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);;/t15-,16-,17-,18+,19-,20+,21+,22+,25+,26-;;/m1../s1

Clave InChI

BMYWWGPEKRLDGW-ZXMGEDLUSA-N

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Descripción general

Sodium glycodeoxycholate is a bile salt that can be used to form biomimicking environments.

Aplicación

Sodium glycodeoxycholate has been used in a study to develop more similar mimetic intestinal fluids to physiological fluids than those developed by mixed bile salt systems (MBS). It has also been used in a study to investigate Ca2+ buffering capability of bile salt micelles.

Acciones bioquímicas o fisiológicas

Induces apoptosis in hepatocytes; may induce DNA cleavage.

Otras notas

Bile Salt

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Hu-He Chen et al.
Guang pu xue yu guang pu fen xi = Guang pu, 30(3), 748-752 (2010-05-26)
In the present article, NaGDC was used to study the Ca(2+)-buffering capability of bile salt micelles. NaGDC is a naturally occurring bile salt which constitutes approximately 10 molar percent of bile salt composition in gallbladder. The authors selected glycine conjugated
Bile salt composition is secondary to bile salt concentration in determining hydrocortisone and progesterone solubility in intestinal mimetic fluids
Huda H Zughaid, et al.
International Journal of Pharmaceutics, 422, 7-7 (2012)
Elisabetta De Angelis et al.
Food & function, 8(4), 1599-1610 (2017-03-16)
Soy is an important component of the human diet thanks to its nutritional value and high protein content; however, it also represents a risk for allergenic consumers due to its potential to trigger adverse reactions in sensitized individuals. The putative
Domenico Trombetta et al.
Nutrients, 12(11) (2020-11-11)
Almond kernels contain phytochemicals with positive health effects in relation to heart disease, diabetes and obesity. Several studies have previously highlighted that almond cell wall encapsulation during digestion and particle size are factors associated with these benefits. In the present
Raina Thakur et al.
Photochemistry and photobiology, 88(5), 1248-1255 (2012-05-23)
Photophysical properties of two widely used antibiotic fluoroquinolone drugs, namely Norfloxacin (NOR) and Ofloxacin (OFL) have been investigated in biomimicking environments formed by bile salts. Experimental results demonstrate that photophysical enhancement and fall of a particular prototropic species are sensitive
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