G9152
Anti-Galactocerebroside antibody produced in rabbit
whole antiserum
Sinónimos:
Galactocerebroside Antibody, Galactocerebroside Antibody - Anti-Galactocerebroside antibody produced in rabbit
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About This Item
Productos recomendados
origen biológico
rabbit
conjugado
unconjugated
forma del anticuerpo
whole antiserum
tipo de anticuerpo
primary antibodies
clon
polyclonal
contiene
15 mM sodium azide
reactividad de especies
human
técnicas
dot blot: 1:50 using galactocerebroside I and II
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... GALC(2581)
Descripción general
Galactocerebroside is the major galactosphingolipid of myelin. It is expressed in the CNS in cell membranes of oligodendrocytes. It is also expressed in Schwann cells in peripheral nerves.
This product is a pooled delipidized antiserum produced in rabbits by repeated injections of a mixture of galactocerebrosides I and II conjugated to keyhole limpet hemocyanin.
Especificidad
The antibody localizes oligodendroglia in cultured cells. It may be used for studying changes in the organization of oligodendroglial membrane sheets in culture. Specificity of the product is determined by dot blotting using galactocerebroside as the antigen.
Inmunógeno
Galactocerebrosides (GalC) I and II conjugated to KLH
Aplicación
Anti-Galactocerebroside antibody produced in rabbit has been used:
- for dot-blot immunoassay and western blot analysis of mouse brain homogenates
- as a primary antibody at a working dilution of 1:50 for immunostaining of muscle tissue of Rana pipiens frogs
- as a primary antibody at a working dilution of 1:500 in immunofluorescence and immunohistochemistry using primary human astroglia
Acciones bioquímicas o fisiológicas
Galactocerebroside is the major galactosphingolipid of myelin. It is expressed in the CNS in cell membranes of oligodendrocytes. It is also expressed in Schwann cells in peripheral nerves. Galactocerebroside is found in serum and cerebral spinal fluid of patients with demyelinating diseases like multiple sclerosis.
Galactocerebroside was shown to play an important role in the processes of normal development and myelination and is known to be an early marker of oligodendrocyte development.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
J Georgiou et al.
Glia, 27(2), 101-109 (1999-07-27)
Perisynaptic Schwann cells (PSCs) envelop axonal terminals and are physiologically distinct from the nearby myelinating Schwann cells (MSCs), which surround the same innervating motor axons. PSCs have special functions at the neuromuscular synapse, where they detect and can modulate neurotransmitter
B Zalc et al.
Brain research, 211(2), 341-354 (1981-05-04)
We have used purified antibodies against galactosylceramide (galCb) and sulfogalactosylceramide (sulf) to study the topographical distribution of these two lipid haptens in the brain of the 30-day-old mouse. This study has been conducted, using the indirect immunofluorescence method, on cerebellum
Lead alters the developmental profile of the galactolipid metabolic enzymes in cultured oligodendrocyte lineage cells
Deng W and Poretz RD
Neurotoxicology, 22(4), 429-437 (2001)
J W Prineas et al.
Laboratory investigation; a journal of technical methods and pathology, 61(5), 489-503 (1989-11-01)
Fresh lesions in the brain and spinal cord of patients with multiple sclerosis who died shortly after the onset of symptoms were examined immunocytochemically for myelin and oligodendrocyte antigens that are known to be sequentially expressed during normal development. Cells
Galactocerebroside is a specific cell-surface antigenic marker for oligodendrocytes in culture.
M C Raff et al.
Nature, 274(5673), 813-816 (1978-08-24)
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