G8764
Gc-globulin from human plasma
≥90% (SDS-PAGE), lyophilized powder (containing sodium chloride and sodium phosphate buffer salt)
Sinónimos:
DBP, Group-Specific Component, Vitamin D Binding Protein
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About This Item
Productos recomendados
origen biológico
human plasma
Nivel de calidad
Análisis
≥90% (SDS-PAGE)
formulario
lyophilized powder (containing sodium chloride and sodium phosphate buffer salt)
mol peso
~52 kDa
técnicas
LC/MS: suitable
solubilidad
H2O: soluble 2 mg/mL
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
human ... GC(2638)
Descripción general
Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.
Gc-globulin from human plasma is encoded by the gene GC, which is mapped to human chromosome 4q13.3.
Gc-globulin or the vitamin D binding protein (DBP) is a 51-58 kDa multifunctional serum glycoprotein synthesized in large quantities by primarily in the liver. It is a member of the albumin gene family and has the characteristic multiple disulfide-bonded, triple domain structure.
Aplicación
Gc-globulin from human plasma has been used:
- as a fluorescent probe for G-actin staining
- as a fluorescent probe to monitor steady-state rate of actin filament disassembly
- as a calibrator for liquid chromatography with mass spectrometry (LC-MS/MS)
Gc-globulin is a multifunctional, albumin-like plasma protein that often requires cell surface binding to mediate some of its diverse functions. It has been used to anlayze its glycosylation patterns.
Acciones bioquímicas o fisiológicas
Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, a part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.
Single nucleotide polymorphism in the gene GC is associated with deficiency of 25-hydroxyvitamin D [25(OH)D].
Nota de preparación
Native Gc-globulin from human plasma
Cláusula de descargo de responsabilidad
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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