G1670
Anti-Glutamate Receptor 4, Metabotropic antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Sinónimos:
Anti-mGluR4
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About This Item
Productos recomendados
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
reactividad de especies
human
disponibilidad
not available in Japan
técnicas
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 3 μg/mL using human neurons, cortex
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... GRM4(2914)
mouse ... Grm4(268934)
rat ... Grm4(24417)
Inmunógeno
synthetic peptide corresponding to the N-terminal extracellular domain of human metabotropic glutamate receptor 4, conjugated to KLH. The immunizing peptide has 100% homology with the rat gene and 89% homology with the mouse gene.
Aplicación
Anti-Glutamate Receptor 4, Metabotropic antibody is suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 3μg/mL using human neurons, cortex.
Acciones bioquímicas o fisiológicas
Glutamate, the excitatory neurotransmitter, is involved in fast excitatory synaptic transmission. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors. The metabotropic form consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Group I binds to phospholipase C and intracellular calcium mobilization, whereas both groups II and III inhibit adenyl cyclase. The metabotropic receptors have some therapeutic potentials. group I receptors have been implicated in post-ischemic neuronal injury, and antagonists of group I appear to have a neuroprotective effect.
Forma física
Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
nwg
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Certificados de análisis (COA)
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W Spooren et al.
Behavioural pharmacology, 14(4), 257-277 (2003-07-03)
Following the molecular cloning in the early 1990s of the metabotropic glutamate receptors (mGlu1-8), research that focused on the physiology, pharmacology and function of these receptors revealed their potential role in CNS disorders. Numerous psychiatric and neurological dis-orders are indeed
Domenico E Pellegrini-Giampietro
Trends in pharmacological sciences, 24(9), 461-470 (2003-09-12)
Metabotropic glutamate receptors of the mGlu(1) and mGlu(5) subtypes exhibit a high degree of sequence homology and are both coupled to phospholipase C and intracellular Ca(2+) mobilization. However, functional differences have been detected for these receptor subtypes when they are
Metabotropic glutamate receptors in the cerebellum with a focus on their function in Purkinje cells.
Thomas Knöpfel et al.
Cerebellum (London, England), 1(1), 19-26 (2003-07-26)
Metabotropic glutamate receptors (mGluRs) are a family of proteins that have seven transmembrane segments and that couple to G proteins. They differ from ionotropic glutamate receptors in that they do not form ion channels but instead affect intracellular chemical messenger
J P Pin et al.
Neuropharmacology, 34(1), 1-26 (1995-01-01)
Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels--termed NMDA, AMPA and kainate receptors--involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to
Peter J Flor et al.
Advances in experimental medicine and biology, 513, 197-223 (2003-02-11)
Metabotropic glutamate receptors form a family of currently eight subtypes (mGluR1-8), subdivided into three groups (I-III). Activation of group-II (mGluR2 and -3) or group-III metabotropic glutamate receptors (mGluR4, -6, -7 and -8) has been established to be neuroprotective in vitro
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